The Buffalo Bills (8-3) travel to meet the New England Patriots (6-5) for Thursday Night Football in Week 13 at Gillette Stadium. Kickoff is scheduled for 8:15 p.m. ET (Prime Video). Below, we analyze Tipico Sportsbook’s lines around the Bills vs. Patriots odds, and make our expert NFL picks and predictions.
The Bills search for a 2nd consecutive Thursday victory after they hung on for a 28-25 win against the Detroit Lions on Thanksgiving Day. Buffalo has scored 23 or more points in 7 of its last 8 games.
The Under is 7-2 in the past 9 games overall for Buffalo, including 2-0 in the first 2 games against AFC East Division opponents.
The Patriots are coming off a 33-26 setback in Minnesota on Thanksgiving Night, snapping a 3-game win and cover streak. The Over cashed against the Vikings, snapping a 3-game Under run, too.
New England has posted 2 wins in 3 games against AFC East foes this season, while also going 2-1 ATS. The Under is 3-0 inside the division for the Pats, too.
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Bills at Patriots odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:57 a.m. ET.
- Moneyline (ML): Bills -190 (bet $190 to win $100) | Patriots +160 (bet $100 to win $160)
- Against the spread: Bills -3.5 (-109) | Patriots +3.5 (-111)
- Over/Under (O/U): 43.5 (O: -110 | U: -110)
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Bills at Patriots key injuries
Bills
- OL Dion Dawkins (ankle) out
- LB Von Miller (knee) out
Patriots
- C David Andrews (thigh) questionable
- OL Yodny Cajuste (calf) questionable
- RB Damien Harris (thigh) out
- CB Marcus Jones (ankle) questionable
- WR Jakobi Meyers (shoulder) questionable
- CB Jalen Mills (groin) questionable
- WR DeVante Parker (groin) questionable
- FS Jabrill Peppers (illness) questionable
- OL Isaiah Wynn (foot) out
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Bills at Patriots picks and predictions
Prediction
Bills 23, Patriots 18
Moneyline
The Bills (-190) are just slightly over my personal money line limit for a singular play.
The Patriots (+160) are a tempting play due to their impressive defense that allows just 307.8 total yards per game (4th) and just 18.4 points per game (6th).
This is an especially tough game for the Pats, however, facing a Buffalo offense that has posted 415.9 total yards per game (2nd), 279.2 passing yards per game (3rd) and 28.1 PPG (2nd).
PASS, and look to the spread instead.
Against the spread
Play the BILLS -3.5 (-109) lightly, laying the 3 and a hook. Buffalo is just 1-3-1 ATS in its last 5 road games, but it’s 7-3-1 ATS in the past 11 games inside the AFC East.
Buffalo is also 3-0-1 ATS in the past 4 trips to Foxboro while going 5-2-1 ATS in the past 8 meetings overall. The road team is 19-7-2 ATS in the past 28 meetings in this series, too.
Over/Under
UNDER 43.5 (-110) is the play in this primetime matchup.
We’ll have temperatures around freezing and winds 9-12 mph, but nothing either of these northern teams can’t handle. In fact, each team might find the weather rather balmy.
However, the defenses are driving the train for this Under play. The Under is 6-0 in the past 6 road games for the Bills, while going 4-1 in their last 5 against teams with winning records. The Under is also 4-0 in the past 4 Thursday appearances for the Bills — including last week against the Lions.
The Patriots have hit the Under in 5 of the past 7 against AFC foes while going 4-1 to the Under in their past 5 games following a straight-up loss.
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