The Baltimore Orioles (35-21) and San Francisco Giants (28-28) meet Friday to kick off a 3-game series. First pitch from Oracle Park is set for 10:15 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Orioles vs. Giants odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting since 2019 when Giants won series 2-1
Baltimore lost 12-8 as +104 home underdogs Wednesday vs. the Cleveland Guardians. The Orioles went 2-4 in their 6-game homestand and now begin a 6-game road stretch. The Orioles went 5-1 on their last road trip.
San Francisco lost 9-4 as -116 home favorites Wednesday vs. Pittsburgh Pirates, dropping the series 2-1. The Giants have lost 3 of their last 4 after having a 3-game win streak.
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Orioles at Giants projected starters
RHP Dean Kremer vs. RHP Logan Webb
Kremer (5-2, 4.58 ERA) makes his 12th start. He has a 1.44 WHIP, 2.6 BB/9 and 7.3 K/9 in 59 innings.
- Last start: Loss, 6 1/3 IP, 3 ER, 5 H, 2 BB, 5 K, in a 5-3 home loss Saturday vs. Texas Rangers
- First start vs. San Francisco
Webb (4-5, 2.75 ERA) makes his 12th start. He has a 1.07 WHIP, 1.8 BB/9 and 9.5 K/9 in 72 innings.
- Last start: Win, 7 IP, 1 ER, 4 H, 1 BB, 11 K, in a 3-1 road win Saturday vs. Milwaukee Brewers
- First start vs. Baltimore
Orioles at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:05 p.m. ET.
- Moneyline (ML): Orioles +135 (bet $100 to win $135) | Giants -160 (bet $160 to win $100)
- Run line (RL)/Against the spread (ATS): Orioles +1.5 (-155) | Giants -1.5 (+125)
- Over/Under (O/U): 8 (O: -105 | U: -115)
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Orioles at Giants picks and predictions
Prediction
Orioles 6, Giants 4
Moneyline
LEAN ORIOLES (+135).
The Giants are mediocre at home, with a 16-13 record, while the Orioles are an exellent road team, with a 18-9 record. The Giants are 0-7 in their last 7 interleague games vs. a right-handed starter.
Run line/Against the spread
PASS.
No need to pay the juice. The moneyline offers a better value.
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Over/Under
LEAN OVER 8 (-105).
The Over is 3-0-1 in Baltimore’s last 4 games following a rest day and 3-0-1 in Kremer’s last 4 starts after scoring 5 runs or more in their previous game. The Giants have gone Over this total in 3 of their last 4 games.
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