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The Baltimore Orioles (65-44) and the Cleveland Guardians (65-42) open a 4-game series Thursday. First pitch from Progressive Field is at 6:40 p.m. ET (ESPN+). Let’s analyze FanDuel Sportsbook’s lines around the Orioles vs. Guardians odds and make our expert MLB picks and predictions for the best bets.
Season series: Guardians lead 2-1
The Guardians swept a quick 2-game series at the Detroit Tigers Monday and Tuesday. They have won 3 in a row, while going 6-2 across the past 8 games. The Under is 6-1 in the past 7 for Cleveland, while cashing at a 12-3 clip in the previous 15 contests.
The Orioles took 3 of 4 games at home from the Toronto Blue Jays earlier this week, including a doubleheader split Monday. Opposite of the Guards, the O’s have hit the Over in 9 of the past 10 games, and 12-2 across the past 14 outings.
These teams met June 24-26 in Baltimore, with Cleveland taking 2 of 3 and the Under hitting in 2 of the contests.
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Orioles at Guardians projected starters
TBD vs. RHP Ben Lively
The Orioles haven’t named a starting pitcher at the time of this publishing.
Lively (9-6, 3.44 ERA) makes his 19th start. He has a 1.17 WHIP, 2.6 BB/9 and 7.8 K/9 through 99 1/3 innings.
- Last start: Win, 6 IP, 1 ER, 3 H (1 solo HR), 2 BB, 6 K in 3-1 victory at Philadelphia Phillies last Friday
- 2024 home splits: 5-1, 2.66 ERA (40 2/3 IP, 12 ER), 1.08 WHIP, .233 opponents’ batting average, 9 BB, 35 K in 7 starts
- Has never faced Orioles
Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.
Orioles at Guardians odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:28 a.m. ET.
- Moneyline (ML): Orioles -108 (bet $108 to win $100) | Guardians -108 (bet $108 to win $100)
- Run line (RL)/Against the spread (ATS): Orioles -1.5 (+136) | Guardians +1.5 (-164)
- Over/Under (O/U): 9.5 (O: -102 | U: -120)
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Orioles at Guardians picks and predictions
Prediction
Guardians 4, Orioles 3
Moneyline
The GUARDIANS (-108) are a strong play in this clash of potential playoff teams.
Lively has been one of the more consistent starting pitchers for Cleveland, and he’ll get the job done against Baltimore in this series opener.
The Guardians are an MLB-best 33-15 at home, easily the best mark in the American League. This should be a close contest, though, as the Orioles are 31-19 on the road, the 2nd-best mark in the AL — behind the Yankees (38-22).
Run line/Against the spread
If you’re a much more conservative bettor, and you don’t want to play the Guardians on the moneyline, Cleveland +1.5 (-164) isn’t priced out of line if you prefer a bit of insurance.
As a favorite, Cleveland is 4-1 on the run line in the past 5 tries.
Over/Under
UNDER 9.5 (-120) is an outstanding bet in this series opener.
The Under has cashed in 3 straight starts for Lively, while cashing at a 12-3 mark in the past 15 outings. At home, Cleveland has hit the Under at a 5-2 clip in the previous 7 outings.
For the O’s, while the Over is 12-2 across the past 14 games, the Under is 2-1 in 3 meetings with Cleveland this season.
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