Arizona State at USC odds, picks and predictions

Analyzing Saturday’s Arizona State at USC odds and lines, with college football expert picks, predictions and best bets.

The Arizona State Sun Devils (1-3, 0-1 Pac-12) take on the USC Trojans (4-0, 2-0) at the Los Angeles Memorial Coliseum Saturday. Kickoff is scheduled for 10:30 p.m. ET (ESPN). Below, we analyze Tipico Sportsbook‘s lines around the Arizona State vs. USC odds, and make our expert college football picks and predictions.

Arizona State lost 34-13 at home vs. the No. 13 Utah Utes last Saturday in its 1st game since firing coach Herm Edwards. The Sun Devils failed to cover as 17-point underdogs in interim coach Shaun Aguano’s debut.

The Under is 6-0-1 in Arizona State’s last 7 games.

USC failed to cover as a 5.5-point favorite in a 17-14 win at the Oregon State Beavers last Saturday. The Trojans scored less than 40 points for the first time this season as QB Caleb Williams went 16-of-36 passing for just 180 yards.

USC is ranked No. 6 in the AFCA Coaches Poll powered by USA TODAY Sports.

Stream select live college football games and full replays: Get ESPN+

Arizona State at USC odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 6:46 p.m. ET.

  • Money line (ML): Arizona State +1300 (bet $100 to win $1,300) | USC -5000 (bet $5,000 to win $100)
  • Against the spread (ATS): +25.5 (-115) | USC -25.5 (-105)
  • Over/Under (O/U): 60.5 (O: -110 | U: -110)

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

Arizona State at USC picks and predictions

Prediction

USC 41, Arizona State 10

Money line

PASS.

Betting $5,000 to profit just $100 on USC (-5000) money line is not realistic. Look to the spread and total for more reasonable opportunities.

Against the spread

BET USC -25.5 (-105).

USC just defeated a much tougher team in Oregon State. The Trojans should coast in this matchup vs. an Arizona State team that continues to underperform. Arizona State had a great opportunity to turn its season around last Saturday in Aguano’s debut as interim coach and still could not cover as big underdogs. Fade the Sun Devils and lay the points.

Over/Under

BET UNDER 60.5 (-110).

USC’s offense should bounce back after an uncharacteristic showing at Oregon State. However, Arizona State has struggled to score this season vs. FBS competition. The Sun Devils’ anemic offense should help keep this game under the total.

Play our free daily Pick’em Challenge and win! Play now!

Want action on this game or any other NCAA football matchup? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow Corey Scott on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:

Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1622]