Arizona Diamondbacks at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s Arizona Diamondbacks at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

The Arizona Diamondbacks (57-51) and San Francisco Giants (59-49) meet Wednesday for game 3 of a 4-game series. First pitch from Oracle Park is set for 9:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Diamondbacks vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Diamondbacks lead 5-4

San Francisco won 4-3 Tuesday as a +101 home underdog to tie the current series at 1 game apiece. Arizona held a 3-0 lead heading into the bottom of the 6th but a 3-run bottom half tied things up and a solo HR in the bottom of the 7th from 1B Lamonte Wade Jr. put the Giants ahead for good.

The Diamondbacks are now 3-7 in their last 10 overall and 1-5 in their last 6 road games. They sit at 29-23 on the road on the year. The Giants are 5-5 in their last 10 and 5-2 in their last 7 home games. San Francisco is 31-24 at home this season.

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Diamondbacks at Giants projected starters

RHP Slade Cecconi vs. RHP Logan Webb

Cecconi makes his 1st career start. He is 4-8 with a 6.38 ERA, 1.38 WHIP, 2.5 BB/9 and 9.1 K/9 through 103 IP for AAA-Reno.

  • Selected in the 1st round of 2020 draft (33rd overall) out of the University of Miami
  • Last start: Loss, 7 IP, 2 ER, 6 H, 0 BB, 5 K in 2-1 home loss to Triple-A Oklahoma City Dodgers Thursday
  • Allowed 2 runs or fewer in 5 of his last 7 starts

Webb (8-9, 3.49 ERA) makes his 23rd start. He has a 1.10 WHIP, 1.5 BB/9 and 8.9 K/9 through 141 2/3 IP.

  • Last outing: Loss, 7 1/3 IP, 3 ER, 6 H, 0 BB, 4 K in a 3-2 home loss Friday vs. Boston Red Sox
  • Career vs. Arizona: 4-2, 2.63 ERA (48 IP, 14 ER), 43 H, 14 BB, 42 K through 8 starts

Diamondbacks at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:37 a.m. ET.

  • Moneyline (ML): Diamondbacks +155 (bet $100 to win $155) | Giants -190 (bet $190 to win $100)
  • Run line (RL)/Against the spread (ATS): Diamondbacks +1.5 (-130) | Giants -1.5 (+105)
  • Over/Under (O/U): 8 (O: -110 | U: -110)

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Diamondbacks at Giants picks and predictions

Prediction

Giants 3, Diamondbacks 2

Moneyline

PASS.

I am not confident in betting on either team to win with recent matchups being so back-and-forth and neither team being particularly hot. Bet on the run line and/or total instead.

Run line/Against the spread

LEAN DIAMONDBACKS +1.5 (-130).

The Diamondbacks are starting a pitcher who has never pitched in the MLB but I like their chances of keeping this game close. The Giants are 2-3 in Webb’s last 5 starts and 1-2 in his last 3 starts vs. Arizona, and recent Arizona-San Francisco matchups are even at 5-5 through the last 10 meetings. The Diamondbacks are also solid on the road.

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Over/Under

BET UNDER 8 (-110). 

The Under is 4-0 in Arizona’s last 4 overall and 8-2 in its last 10.

The Under has cashed in 5 of San Francisco’s last 6 outings, 2-1 in Webb’s last 3 starts vs. Arizona and 3-1 in Webb’s last 4 starts overall.

The Under is also 3-0 in the last 3 meetings between these teams.

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