Arizona Diamondbacks at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s Arizona Diamondbacks at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Arizona Diamondbacks (78-61) and San Francisco Giants (68-71) play the 2nd game of a 3-game series Wednesday. First pitch from Oracle Park is at 9:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Diamondbacks vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Diamondbacks lead 5-3

The Diamondbacks won 8-7 win in the Tuesday opener, allowing 5 runs in the final 2 innings to make it close. They have won 7 straight games on the road.

The Giants have lost 3 games in a row and 5 of their last 6. They are 3-8 in their last 11 games.

Diamondbacks at Giants projected starters

RHP Zac Gallen vs. RHP Hayden Birdsong

Gallen (10-6, 3.87 ERA) makes his 24th start. He has a 1.31 WHIP, 3.2 BB/9 and 8.8 K/9 through 121 innings.

  • Last start: No-decision, 5 IP, 5 ER, 6 H, 2 BB, 7 K in 10-9 home loss to Los Angeles Dodgers Friday
  • Has allowed 1 ER or fewer in his last 4 starts after giving up 3+ ER
  • Career vs. Giants: 4-5, 4.44 ERA (77 IP, 38 ER), 1.25 WHIP, 9.6 K/9 in 14 starts

Birdsong (3-4, 5.14 ERA) makes his 12th start. He has a 1.43 WHIP, 5.5 BB/9 and 11.0 K/9 through 49 innings.

  • Last start: Loss, 3 2/3 IP, 5 ER, 4 H, 4 BB, 6 K in 6-0 road loss to Milwaukee Brewers Thursday
  • Did not make it out of 5th inning in any of his 5 August starts
  • Has never faced Arizona

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Diamondbacks at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:45 a.m. ET.

  • Moneyline (ML): Diamondbacks -145 (bet $145 to win $100) | Giants +120 (bet $100 to win $120)
  • Run line (RL)/Against the spread (ATS): Diamondbacks -1.5 (+115) | Giants +1.5 (-140)
  • Over/Under (O/U): 7.5 (O: -125 | U: -105)

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Diamondbacks at Giants picks and predictions

Prediction

Diamondbacks 7, Giants 3

Moneyline

Arizona’s (-145) bats are hot. They have scored 6 or more runs in 5 straight games and in 9 of their last 12.

Gallen has allowed 1 ER or fewer in his last 4 starts following a 3+ ER outing.

Arizona is 6-2 in his last 8 starts.

The Diamondbacks have now won 7 games in a row, and the Giants have lost 4 of their last 5 at home.

Expect the Diamondbacks to pick up a win and series victory, but you get better odds on the run line.

PASS.

Run line/Against the spread

Before Tuesday’s opener, the last 9 wins for Arizona were by 2 or more runs. Ten of the 13 wins they have when Gallen starts are by multiple runs. Four of their 5 wins over the Giants have been by multiple runs.

BET DIAMONDBACKS -1.5 (+115).

Over/Under

Six of the 8 games these teams have played this season have had at least 8 total runs.

The Diamondbacks are averaging 8.6 runs themselves over their last 5 games.

BET OVER 7.5 (-125).

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