Arizona Diamondbacks at San Francisco Giants odds, picks and predictions

Analyzing Tuesday’s Arizona Diamondbacks at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Arizona Diamondbacks (77-61) and San Francisco Giants (68-70) open a 3-game series Tuesday. First pitch from Oracle Park is scheduled for 9:45 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Diamondbacks vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Diamondbacks lead 4-3

The Diamondbacks are coming off a 2-5 homestand, losing both series they played. They just lost 3 out of 4 games to the LA Dodgers, including an 11-6 defeat in the series finale Monday. They are in 3rd place in the NL West, 6 games behind the Dodgers and sit in the 2nd Wild Card spot, 1 game behind San Diego for the top Wild Card.

The Giants have lost 4 of their last 5 and back-to-back games to lose their road series to the Miami Marlins. Before a day off Monday, they lost 7-5 in the series finale. They are 6½ games behind in the Wild Card race.

Diamondbacks at Giants projected starters

RHP Ryne Nelson vs. TBD

Nelson (9-6, 4.22 ERA) makes his 24th start and 26th appearance. He has a 1.28 WHIP, 2.0 BB/9 and 7.4 K/9 through 136 1/3 innings.

  • Last start: No-decision, 6 1/3 IP, 2 ER, 8 H, 0 BB, 4 K in 3-2 home loss to New York Mets Thursday
  • Allowed 2 or fewer ER in 4 straight starts for 2.42 ERA
  • 2024 vs. Giants: 0-0, 1.86 ERA (9 2/3 IP), 0.83 WHIP, 0.9 K/9 in 2 starts
  • Career vs. Giants: 1-0, 2.89 ERA (28 IP, 9 ER), 1.04 WHIP, 3.9 K/9 in 5 starts

The Giants had not yet announced a starter, but LHP Kyle Harrison (7-6, 4.22 ERA) could potentially make his 24th start. He has a 1.31 WHIP, 3.0 BB/9 and 8.5 K/9 through 121 2/3 innings.

  • Last start: Loss, 4 2/3 IP, 5 ER, 4 H, 3 BB, 7 K in 5-3 road loss to Milwaukee Brewers Wednesday
  • Went 1-2 with 6.29 ERA in 5 starts in August
  • Career vs. Diamondbacks: 0-1, 5.40 ERA (10 IP, 6 ER), 1.50 WHIP, 9.0 K/9 in 2 starts in 2024

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Diamondbacks at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:43 a.m. ET.

  • Moneyline (ML): Diamondbacks -115 (bet $115 to win $100) | Giants -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Diamondbacks -1.5 (+150) | Giants +1.5 (-185)
  • Over/Under (O/U): 7.5 (O: -110 | U: -110)

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Diamondbacks at Giants picks and predictions

Prediction

Diamondbacks 6, Giants 5

Moneyline

The DIAMONDBACKS (-115) have won 6 straight games on the road, and  scoring runs has not been a problem. They have scored 6 or more runs in 4 straight games and in 8 of their last 11.

The Giants have not scored more than 5 runs in 14 straight games.

Nelson has been pitching very well, while Harrison struggled more in August.

BET DIAMONDBACKS (-115).

Run line/Against the spread

The Diamondbacks’ last 9 wins have been by multiple runs.

However, 3 of the Giants’ last 6 losses have been by only 1 run.

Betting the Giants to cover the +1.5 at -185 odds doesn’t make sense. While betting the Diamondbacks to cover has a nice payout, after losing 5 of their last 7, a simple win on the moneyline is the way to go.

PASS.

Over/Under

Nine of the Diamondbacks’ last 11 games have had 8 or more total runs. Five of the 7 games between the Diamondbacks and Giants have had at least 8 runs.

BET OVER 7.5 (-110).

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