Arizona Diamondbacks at San Francisco Giants odds, picks and prediction

Analyzing Tuesday’s Arizona Diamondbacks at San Francisco Giants odds and lines, with MLB picks and predictions.

The Arizona Diamondbacks (50-106) open their final road series of the year against the NFL West-leading San Francisco Giants (102-54). First pitch is at 9:45 p.m. ET at Oracle Park. Let’s analyze the lines around the Diamondbacks vs. Giants odds with MLB picks and predictions.

Diamondbacks RHP Luke Weaver (3-6, 4.38 ERA) makes his 13th start. He has a 1.15 WHIP, 2.3 BB/9 and 8.2 K/9 through 61 2/3 IP.

  • Weaver has lost his last three starts, allowing three or more earned runs in each.
  • The Diamondbacks have not won a road start of his since they beat the Rockies 10-8 in Colorado April 6.

Giants RHP Logan Webb (10-3, 3.04 ERA) makes his 25th start. He has a 1.12 WHIP, 2.2 BB/9 and 9.5 K/9 through 136 1/3 IP.

  • The Giants lost his last start, but before that, they won eight consecutive starts of his. They are 19-5 when he starts.
  • While this is the 17th game between the Diamondbacks and Giants, it will be Webb’s first time this season against them.

Diamondbacks at Giants odds, lines, picks and prediction

MLB odds courtesy of Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 2:00 p.m. ET.

  • Money line: Diamondbacks +220 (bet $100 to win $220) | Giants -280 (bet $280 to win $100)
  • Against the spread/ATS: Diamondbacks +1.5 (+102) | Giants -1.5 (-125)
  • Over/Under: 7.5 (O: -125 | U: +100)

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Prediction

Giants 6, Diamondbacks 3

Money line (ML)

The Giants are 14-2 against the Diamondbacks this season. They have won 16 of their last 20 games. They are 49-26 at home this season and 19-5 overall when Webb starts.

The Diamondbacks have only five wins in their last 21 games. Their 30-48 road record is the worst in the National League and second-worst in the majors.

There isn’t a ton in value in this bet but it is a sure win. Take the GIANTS (-280).

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Run line/Against the spread (ATS)

At 36-42 ATS on the road, the Diamondbacks have the fifth-worst mark in the majors. Those last seven losses have all been by at least two runs. Nine of their 14 losses to the Giants have been by two or more runs.

The Giants are third in the majors with a 41-34 home ATS record. 13 of their 16 wins in the last 20 games have been by at least two runs.

Take the GIANTS -1.5 (-125).

Over/Under (O/U)

Thirteen of the 16 games between the two teams this season have had totals of 8 or more runs.

The Giants’ last six games and 14 of their last 20 have all had at least eight runs.

Twelve of the Diamondbacks’ last 17 have had eight or more runs.

Take OVER 7.5 (-125).

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