Arizona Diamondbacks at San Diego Padres odds, picks and predictions

Analyzing Wednesday’s Arizona Diamondbacks at San Diego Padres odds and lines, with MLB expert picks and predictions.

The Arizona Diamondbacks (65-70) close out their 3-game road series against the San Diego Padres (75-62) Wednesday. First pitch at Petco Park is 8:40 p.m. ET (FS1). Let’s analyze Tipico Sportsbook‘s lines around the Diamondbacks vs. Padres odds with MLB picks and predictions.

Season series: Padres lead 10-4 after splitting the first 2 games of series

The Diamondbacks’ bullpen blew another save Tuesday night as Ian Kennedy allowed 2 runs in the bottom of the 9th for a 6-5 loss. It was his 6th blown save the team’s 21st of the season. The loss was just their 3rd in their last 12 games.

The Padres snapped a 3-game losing streak with the win. They have 7 wins in their last 11 games and maintain a 3-game lead for the final NL wild-card berth.

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Diamondbacks at Padres projected starters

LHP Tommy Henry vs. RHP Yu Darvish

Henry (3-3, 4.83 ERA) makes his 7th start. He has a 1.48 WHIP, 4.5 BB/9 and 6.5 K/9 in 31 2/3 IP.

  • Rookie coming off his worst start, allowing 7 R on 8 H in 4 IP of an 18-2 loss to the Philadelphia Phillies Aug. 31
  • In 3 of his 4 starts prior to that outing, he allowed only 1 run.

Darvish (12-7, 3.26 ERA) makes his 26th start. He has a 0.97 WHIP, 1.7 BB/9 and 9.0 K/9 in 162 2/3 IP.

  • Struck out 9 and allowed only 2 H in 7 scoreless IP against the Los Angeles Dodgers in his last start Friday
  • Is 2-0 with 1.80 ERA in 3 starts against Arizona this season

Diamondbacks at Padres odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:09 a.m. ET.

  • Money line (ML): Diamondbacks +175 (bet $100 to win $175) | Padres -220 (bet $220 to win $100)
  • Run line (RL)/Against the spread (ATS): Diamondbacks +1.5 (-120) | Padres -1.5 (+100)
  • Over/Under (O/U): 7.5 (O: -130 | U: +105)

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Diamondbacks at Padres picks and predictions

Prediction

Padres 6, Diamondbacks 4

Money line

The Padres get to turn to Darvish in the series finale. He has dominated the Diamondbacks in 2022 and has been effective in his career against them.

Henry was knocked around in his last start against the Phillies.

While Arizona has played better recently, the D-backs are 28-36 on the road this season and are 25-40 against teams with winning records.

Their best chance to pick up a series win was Tuesday night with Merrill Kelly starting.

But with the price on Wednesday’s money line for the Padres, PASS and look to the spread and total for your bets.

Run line/Against the spread

The Padres are the league’s worst team at covering the spread at home this season at 21-44 ATS. They have failed to cover the spread in either of the first 2 games of the series.

However, 7 of the Padres’ 10 wins over the Diamondbacks have been by 2 or more runs.

The Diamondbacks are 10-2 ATS in their last 12 games and 80-55 ATS overall this season, but they have had ATS sweeps only 4 times all season and Darvish is one of the less likely pitchers to do it against, based on their performance against him this year.

Take the PADRES -1.5 (+100).

Over/Under

Nine of the 14 game between the 2 teams have had totals of 7 or fewer runs. The Diamondbacks have had totals of 7 or fewer runs in 4 of their last 6 games while 11 of Arizona’s last 16 have had 8 or more runs.

Five of the Padres’ last 6 have had 8 or more runs.

Five of Henry’s 6 starts have had totals of 8 or more runs.

Take OVER 7.5 (-130).

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