Arizona Diamondbacks at San Diego Padres odds, picks and predictions

Analyzing Saturday’s Arizona Diamondbacks at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The Arizona Diamondbacks (30-34) and San Diego Padres (33-34) meet Saturday for the 3rd game of a 4-game series. First pitch from Petco Park is set for 8:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Diamondbacks vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: San Diego leads 3-2

San Diego routed Arizona 10-3 in the 2nd game of the series Friday while cashing as a -135 home favorite. The Diamondbacks were trailing 5-3 at the end of the 7th inning, but the Padres scored 5 more runs in the 8th to put the game away.

RHP Michael King picked up the win, allowing just 4 hits and 1 walk with 5 K’s in 5 scoreless innings. Friday’s win ended a 5-game losing streak for the Padres.

Diamondbacks at Padres projected starters

RHP Ryne Nelson vs. RHP Matt Waldron

Nelson (3-4, 5.44 ERA) makes his 10th start. He has a 1.60 WHIP, 2.4 BB/9 and 6.0 K/9 in 48 innings.

  • Last start: No-decision, 7 2/3 IP, 2 ER, 6 H, 0 BB, 1 K in 4-2 home win over San Francisco Giants Monday
  • 2024 vs. San Diego: 1-0, 7.20 ERA (5 IP, 4 ER), 8 H, 1 BB, 3 K in 1 start, an 11-4 home win May 5
  • Career vs. San Diego: 2-2, 6.23 ERA (30 1/3 IP, 21 ER), 1.42 WHIP, 6.5 K/9 in 6 starts

Waldron (3-5, 3.98 ERA) makes his 13th start. The rookie has a 1.26 WHIP, 2.7 BB/9 and 9.1 K/9 in 63 1/3 innings.

  • Last start: No-decision, 6 1/3 IP, 1 ER, 2 H, 0 BB, 4 K in 2-1 loss at Los Angeles Angels Monday
  • 2024 vs. Arizona: 0-1, 21.00 ERA (3 IP, 7 ER), 8 H, 3 BB, 2 K in 1 start, an 11-4 road loss May 5
  • Career vs. Arizona: 0-2, 13.50 ERA (8 IP, 12 ER), 2.38 WHIP, 7.9 K/9 in 2 starts

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Diamondbacks at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:15 a.m. ET.

  • Moneyline (ML): Diamondbacks +120 (bet $100 to win $120) | Padres -145 (bet $145 to win $100)
  • Run line (RL)/Against the spread (ATS): Diamondbacks +1.5 (-175) | Padres -1.5 (+145)
  • Over/Under (O/U): 8 (O: -105 | U: -115)

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Diamondbacks at Padres picks and predictions

Prediction

Diamondbacks 5, Padres 3

Moneyline

LEAN DIAMONDBACKS (+120).

Arizona is 2-1 in its last 3 road games, while the Padres are only 1-2 in their last 3 at home. The Diamondbacks are also 3-1 in their last 4 meetings with the Padres in San Diego.

This is only a lean because Arizona is just 6-4 in the last 10 meetings. Arizona is also just 5-5 in its last 10 games overall, while the Padres are 4-6.

Run line/Against the spread

PASS.

I expect the Diamondbacks to cover as +1.5 (-175) underdogs, but the line is too heavy to risk betting on as currently set. Bet on the moneyline and/or O/U instead.

Over/Under

BET OVER 8 (-105).

The Over has hit in 3 of Arizona’s last 4 games overall and is 4-1 in its last 5 on the road. For San Diego, the Over is 2-1 in its last 3 home games. The Over has also hit in 3 of the last 4 Arizona-San Diego matchups overall and is 3-1 in the last 4 meetings in San Diego.

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