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The Arizona Cardinals (1-3) are on the road in Week 5 to face the San Francisco 49ers (2-2). Kickoff from Levi’s Stadium is at 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Cardinals vs 49ers odds, and make our expert NFL picks and predictions.
The Cardinals have lost 2 straight and are coming off their worst loss in the last 2 seasons, falling 42-14 at home to the Washington Commanders as 3.5-point favorites.
The Niners completely dominated the New England Patriots in a 30-13 home win, covering the 10.5-points spread as favorites, and sacking the Patriots 6 times.
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Cardinals at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 11:36 p.m. ET.
- Moneyline (ML): Cardinals +280 (bet $100 to win $280) | 49ers -350 (bet $350 to win $100)
- Against the spread (ATS): Cardinals +7 (-105) | 49ers -7 (-115)
- Over/Under (O/U): 49 (O: -110 | U: -110)
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Cardinals at 49ers key injuries
Cardinals
- OL Kelvin Beachum (hamstring) questionable
- TE Trey McBride (ribs) questionable
- K Matt Prater (knee) questionable
- DL Khyiris Tonga (knee) questionable
- CB Garrett Williams (groin) out
49ers
- WR Chris Conley (oblique) doubtful
- WR Jacob Cowing (shoulder) questionable
- DT Kalia Davis (knee) questionable
- LB Demetrius Flannigan-Fowles (calf) out
- DL Yetur Gross-Matos (knee) out
- TE George Kittle (ribs) questionable
- LB Fred Warner (ankle) questionable
- CB Isaac Yiadom (thigh) questionable
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Cardinals at 49ers picks and predictions
Prediction
49ers 31, Cardinals 27
Moneyline
In 2023, when the Cardinals lost 37-14 to the LA Rams, they bounced back with an outright road win the following week. Otherwise, they have been consistently competitive.
The 49ers have the league’s No. 2 rusher in RB Jordan Mason and the Cardinals struggle to stop the run, allowing 130 yards to the Bills, 187 to the Lions and 216 to Washington last week.
The Cardinals also struggle on 3rd down, allowing opponents to convert 45.5% of the time, and the Niners are 7th in 3rd-down offense at 44.7%.
It’s a bad matchup for Arizona, but don’t be the Niners on the M/L at that price (-350).
PASS.
Against the spread
Both teams are 2-2 ATS. The Cardinals are 0-2 ATS in their last 2 games. But the 49ers allow opponents to convert on 46% of their 3rd downs and are very average against the run (4.1 yards per attempt allowed), which will allow the Cardinals to keep up offensively.
BET CARDINALS +7 (-105).
Over/Under
The Over is 3-1 in both the Cardinals’ and the 49ers’ 1st 4 games this season.
Their last 3 meetings have had over 49 points.
The Niners have scored at least 30 twice this season and the Cardinals have allowed over 30 twice.
BET OVER 49 (-110).
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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