Arizona at USC odds, picks and predictions

Analyzing Saturday’s Arizona at USC odds and lines, with college football expert picks, predictions and best bets.

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The Arizona Wildcats (3-2, 1-1 Pac-12) visit the No. 9 USC Trojans (5-0, 3-0) Saturday. Kickoff from Los Angeles Memorial Coliseum is set for 10:30 p.m. ET (ESPN). Below, we analyze BetMGM Sportsbook’s lines around the Arizona vs. USC odds, and make our expert college football picks and predictions.

Arizona fell 31-24 at home against Washington last week but covered as a 20-point underdog. QB Noah Fifita went 27 of 39 for 232 yards with 3 touchdowns and an interception. His favorite target was WR Jacob Cowing, who had 9 receptions for 70 yards and a TD, while WR Tetairoa McMillan finished with 6 catches for 45 yards and 2 scores. Arizona’s defense had no answers for Heisman Trophy candidate and Washington QB Michael Penix Jr., who threw for 363 yards on 30-of-40 attempts.

USC took down Colorado 48-41 last week but failed to cover as a 22.5-point road favorite. QB Caleb Williams went 30 of 40 for 403 yards and 6 TDs with an INT in the victory. Last season’s Heisman winner spread it around as 5 different Trojans caught TDs with WR Brenden Rice (5 receptions, 81 yards) hauling in 2. The Trojans led by as many as 27 at one point — 48-21 late in the 3rd quarter — before yielding 20 unanswered points before thwarting Buffaloes’ comeback.

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Arizona at USC odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 11:45 p.m. ET.

  • Moneyline (ML): Arizona +1000 (bet $100 to win $1,000) | USC -2000 (bet $2,000 to win $100)
  • Against the spread (ATS): Arizona +21 (-110) | USC -21 (-110)
  • Over/Under (O/U): 71.5 (O: -110 | U: -110)

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Arizona at USC picks and predictions

Prediction

USC 52, Arizona 24

Moneyline

PASS.

USC (-2000) has been rolling this season and will more than likely continue that dominance Saturday. However, at -2000 odds, there is no value and absolutely no reason to put anything on the moneyline.

Against the spread

LEAN USC -21 (-110).

Williams and USC have looked phenomenal through this first chunk of the season, averaging 555.0 yards of offense. While the Trojans only beat the Buffaloes by 7 points last week, USC had multiple leads of 21 or more. Giving credit to Colorado, it was able to claw its way back into that game, but this week, Arizona will be unable to keep up.

Over/Under

BET OVER 71.5 (-110).

The Trojans have eclipsed 72 points in 3 of their 5 games and have scored at least 42 points in each. Arizona has scored at least 24 points in 4 of its 5 games.

While the burden will most likely fall on USC in order to hit this Over, its offense has shown that it is more than capable of doing so, especially in front of its home fans. The Trojans have scored at least 56 points in each of their 3 home games this season.

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