AFC Divisional Round: Cincinnati Bengals at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Cincinnati Bengals at Buffalo Bills odds and lines, with expert NFL picks, predictions and best bets.

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The Cincinnati Bengals (13-4) visit the Buffalo Bills (14-3) Sunday in an AFC Divisional Round matchup at Highmark Stadium with a 3 p.m. ET kickoff (CBS). Below, we analyze Tipico Sportsbook’s lines around the Bengals vs. Bills odds, and make our expert NFL picks and predictions.

The game we wanted in Week 17 will finally take place with this showdown in Western New York. When the 1st meeting was canceled in the 1st quarter after Bills S Damar Hamlin required CPR on the field, the host Bengals were leading 7-3. QB Joe Burrow was 5-for-5 passing with a TD, but he also had a full complement of offensive linemen in front of him.

Sunday, he won’t have LT Jonah Williams (knee) and RG Alex Cappa (ankle), who have been ruled out, joining RT La’el Collins (torn ACL, out for season). Missing the trio will make it difficult for the Bengals to move the ball, something they failed to do well in their 24-17 Wild Card victory over the Baltimore Ravens as they only had 234 yards on offense.

The Bills, despite the scoreboard being close in their playoff-opening 34-31 victory over the visiting Miami Dolphins dominated the stats. If not for 2 INTs by QB Josh Allen and a Miami fumble return for a TD, Buffalo would have won easily — Allen threw for 352 yards and 3 TDs on top of his 2 picks.

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Bengals at Bills odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated on Friday at 9:26 p.m. ET.

  • Moneyline (ML): Bengals +200 (bet $100 to win $200) | Bills -240 (bet $240 to win $100)
  • Against the spread (ATS): Bengals +5.5 (-106) | Bills -5.5 (-114)
  • Over/Under (O/U): 49 (O: -109 | U: -111)

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Bengals at Bills key injuries

Bengals

  • OL Alex Cappa (ankle) out
  • OL La’el Collins (knee) out — injured reserve
  • CB Tre Flowers (hamstring) doubtful
  • OL Jonah Williams (knee) out

Bills

  • DB Damar Hamlin out — IR
  • DL DaQuan Jones (calf) questionable
  • DL Jordan Phillips (shoulder) questionable

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Bengals at Bills picks and predictions.

Prediction

Bills 27, Bengals 17

Moneyline

Buffalo (-240) will win, but risking 2.4 times the potential profit is not a wager worth making.

I could see adding the Bills (-240) to a parlay, however.

Against the spread

BET BUFFALO -5.5 (-114).

This line takes into account the Bills’ struggles against the Dolphins last week. It’s not taking into account the Bengals missing 3 starters on their offensive line. The Bills defense will take advantage, pressuring Burrow and limiting the production of RB Joe Mixon.

The Dolphins offensive line held up well against the Bills with QB Skylar Thompson time making a few key plays. Burrow will not have the same amount of time and will find it difficult to move the team downfield.

As mentioned, the Bengals only produced 234 offensive yards against the Ravens. A 98-yard fumble return in the 4th quarter by DL Sam Hubbard turned out to be the difference.

This game will not be close enough for a play like that to keep Cincy within striking distance.

Over/Under

UNDER 49 (-111) is the way to go.

While the Bills have been scoring and giving up points — as shown in their 34-31 win over the Dolphins — the Bengals will struggle to score with 3 starting offensive linemen out.

Look for Buffalo to jump out to an early lead and keep the undermanned Bengals at bay. The O/U line of 49 is a bit too high.

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