San Francisco 49ers at Seattle Seahawks odds, picks and predictions

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The San Francisco 49ers (2-3) take on the Seattle Seahawks (3-2) Thursday in a NFC West showdown. Kickoff from Lumen Field is set for 8:15 p.m. ET (Prime Video). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Seahawks odds, and make our expert NFL picks and predictions.

Niners fans began sounding the alarms after a 24-23 loss to the Arizona Cardinals as 7.5-point favorites at home Sunday. This team was expected to be the best team in the NFC, and now they’re in danger of going 2-4 in a divisional battle in a hostile environment. QB Brock Purdy was 19-for-35 for 244 yards, 1 TD and 2 INTs last week. WR Brandon Aiyuk took most of that attention with 8 grabs for 147 yards on 12 targets.

The Seahawks have dropped 2 straight after a 29-20 letdown against the New York Giants as 7-point faves Sunday. QB Geno Smith was 28-for-40 for 284 yards, 1 TD and 0 INTs. The Seahawks got nothing going on the ground. Outside of Smith rushing for 72 yards on 4 carries, RBs Kenneth Walker III and Zach Charbonnet combined for 7 carries for 30 yards.

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49ers at Seahawks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Wednesday at 1:59 p.m. ET.

Moneyline (ML): 49ers -185 (bet $185 to win $100) | Seahawks +150 (bet $100 to win $150)
Against the spread (ATS): 49ers -3.5 (-105) | Seahawks +3.5 (-115)
Over/Under (O/U): 49 (O: -110 | U: -110)

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49ers at Seahawks key injuries

49ers

S Talanoa Hufanga (wrist) questionable
TE George Kittle (ribs) questionable
RB Christian McCaffrey (Achilles) out
PK Jake Moody (ankle) out
CB Charvarius Ward (knee) questionable
LB Fred Warner (ankle) questionable

Seahawks

LB Derick Hall (foot) questionable
FS Julian Love (hamstring) questionable
DT Byron Murphy (hamstring) questionable
LB Uchenna Nwosu (thigh) out

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49ers at Seahawks picks and predictions

Prediction

49ers 24, Seahawks 21

Moneyline

I’m not touching this 49ers ML with a 10-foot pole. The Seahawks are 2-1 at home this year, and they’re in a situation where they need a win, too. The thing that moves the needle for me, though, is the Niners’ rushing attack. RB Jordan Mason has averaged 107.2 rushing yards per game and topped 82 yards in 4 of 5. The Seahawks have allowed the 8th-most rushing yards to RBs this season. Take JORDAN MASON OVER 81.5 RUSHING YARDS (-115).

Against the spread

I like Seattle here and actually give them a shot to win outright at home. The Niners have beaten them 5 straight times, but they’re not getting much from anyone outside of Mason, Aiyuk and sometimes Kittle. Take the SEAHAWKS +3.5 (-115).

Over/Under

These teams haven’t had a total this large in 6 matchups, dating back to 2021. The Over is 3-2-1 in that span. Seattle is 4-1 O/U thus far, and San Fran is 3-2. I think the total has overcorrected to that, and I don’t see it going north of 49.

Take the UNDER 49 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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