Chicago White Sox at San Diego Padres odds, picks and predictions

Analyzing Sunday’s Chicago White Sox at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (89-66) welcome the Chicago White Sox (36-119) to Petco Park Sunday for the finale of a 3-game series. First pitch is set for 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the White Sox at Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 2-0

The Padres beat the White Sox 3-2 to open the series Friday and then continued that streak with a 6-2 win Saturday, closing as heavy favorites in both. They have won 7 of their last 8 games and sit 2nd in the NL West. San Diego is 44-36 at home on the season and 79-76 against the spread (ATS).

The White Sox did sustain a 3-game winning streak Sept. 14-16, but are now riding a 4-game skid. They lost a series 2-1 to the Los Angeles Angels Monday through Wednesday. Chicago, despite that win streak, has still dropped 8 of its last 11 games. It is 16-61 on the road and 63-92 ATS.

White Sox at Padres projected starters

RHP Sean Burke vs. RHP Yu Darvish

Burke (1-0, 2.25 ERA) makes his 2nd start and 3rd appearance. He has a 1.38 WHIP, 3.4 BB/9 and 9.0 K/9 through 8 innings.

  • Last start: Win, 5 IP, 2 ER, 5 H, 2 BB, 5 K in 4-3 home victory over Oakland A’s Sunday
  • 2024 stats with Triple-A Charlotte: 2-6, 4.62 ERA (64 1/3 IP, 33 ER), 1.29 WHIP, 12.0 K/9 in 16 starts
  • Has never faced Padres

Darvish (6-3, 3.21 ERA) makes his 15th start. He has a 1.11 WHIP, 2.4 BB/9 and 8.4 K/9 through 70 innings.

  • Last start: Win, 6 IP, 0 ER, 3 H, 2 BB, 3 K in 3-1 home victory over Houston Astros Monday
  • 2024 home stats: 3-3, 3.75 ERA (48 IP, 20 ER), 1.21 WHIP, 8.3 K/9 in 10 starts
  • Career vs. White Sox: 3-2, 3.57 ERA (45 1/3 IP, 18 ER), 1.30 WHIP, 9.7 K/9 in 7 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

White Sox at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 9:20 a.m. ET.

  • Moneyline (ML): White Sox +280 (bet $100 to win $280) | Padres -350 (bet $350 to win $100)
  • Run line (RL)/Against the spread: White Sox +2.5 (-130) | Padres -2.5 (+110)
  • Over/Under (O/U): 7.5 (O: -120 | U: +100)

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White Sox at Padres picks and predictions

Prediction

Padres 5, White Sox 2

Moneyline

PASS.

The Padres (-350) are again a hefty favorite in this one, so much so that there is no moneyline play. The White Sox are unlikely to avoid a sweep here.

Run line/Against the spread

BET PADRES -2.5 (+110).

The Padres have been winning with ease as of late. They won a series against the Astros 2-1 Monday through Wednesday and swept the San Francisco Giants in 3 games Sept. 13-15.

The White Sox have lost 2 of their last 4 games by more than 2 runs. Chicago has scored a total of 7 runs over its last 4 games and will be facing a strong starting option in Darvish. Expect the Padres to again win by a sizable margin, and take PADRES -2.5 (+110).

Over/Under

BET UNDER 7.5 (+100).

The White Sox haven’t been able to score consistently as of late and have gone Under in 3 of their last 4 games. They are 0-3-1 O/U in that stretch. They are 66-80 O/U on the season. Chicago is 3-8-1 O/U in its last 12.

The Padres have gone Under in 5 of their last 6 games (0-5-1 O/U) and allowed a total of just 4 runs over their last 3.

Take UNDER 7.5 (+100).

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