St. Louis Cardinals at Chicago Cubs odds, picks and predictions

Analyzing Saturday’s St. Louis Cardinals at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The St. Louis Cardinals (56-54) and Chicago Cubs (54-58) play the 3rd game of a 4-game series Saturday. First pitch from Wrigley Field is set for 2:20 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the Cardinals vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cardinals lead 6-5

St. Louis dropped another game at Wrigley 6-3 Friday night. RHP Erick Fedde was roughed up in his debut for the Cardinals (5 IP, 5 ER, 6 H, 2 HR, 0 BB, 4 K). All 3 of the Cardinals’ runs were scored on bases-loaded walks. The Cardinals are 27-29 on the road and 56-54 against the spread (ATS).

The Cubs won their 3rd straight game Friday behind homers from C Christian Bethancourt and 1B Michael Busch in a 5-run 2nd inning. RHP Javier Assad held St. Louis to 1 earned run but only lasted 4 1/3 innings. Chicago is 29-25 at Wrigley Field and 52-60 ATS

Cardinals at Cubs projected starters

RHP Kyle Gibson vs. RHP Jameson Taillon

Gibson (7-4, 3.97 ERA) makes his 21st start. He has a 1.34 WHIP, 3.7 BB/9 and 8.1 K/9 in 113 1/3 IP.

  • Last start: Loss, 5 IP, 2 ER, 6 H, 3 BB, 0 K in 14-3 home loss against Washington Nationals July 27
  • 2024 road splits: 5-1, 3.13 ERA (60 1/3 IP, 21 ER), 1.08 WHIP, 9.5 K/9 in 10 starts
  • 2024 vs. Cubs: 1-0, 3.27 ERA (11 IP, 4 ER), 1.36 WHIP, 7.4 K/9 in 2 starts

Taillon (7-6, 3.35 ERA) makes his 19th start. He has a 1.17 WHIP, 1.9 BB/9 and 7.1 K/9 in 104 2/3 IP.

  • Last start: Loss, 4 1/3 IP, 6 ER, 6 H, 1 BB, 4 K in 7-1 road loss to Cincinnati Reds Monday
  • 2024 home splits: 5-3, 2.68 ERA (57 1/3 IP, 17 R (16 ER), 1.14 WHIP, 8.0 K/9 in 9 starts
  • 2024 vs. Cardinals: 1-1, 4.15 ERA (17 1/3 IP, 8 ER), 1.50 WHIP, 4.7 K/9 in 3 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Cardinals at Cubs odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:15 a.m. ET.

  • Moneyline (ML): Cardinals +100 (bet $100 to win $100) | Cubs -118 (bet $118 to win $100)
  • Run line (RL)/Against the spread: Cardinals -1.5 (+164) | Cubs +1.5 (-200)
  • Over/Under (O/U): 7.5 (O: -115 | U: -105)

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Cardinals at Cubs picks and predictions

Prediction

Cubs 6, Cardinals 4

Moneyline

BET CUBS (-118).

All the momentum is with the Cubs right now, and I’m going to ride that into a victory Saturday. Taillon has a 2.68 ERA at home and has won 2 of his last 3 starts at Wrigley. He just beat the Cardinals at Busch Stadium July 14. Chicago’s ERA at home is also nearly a full point than its ERA in away games (3.28 vs. 4.27).

Gibson does not have a good history against Chicago with a record of 1-4 and an ERA of 5.46. He had a 3.33 ERA in May, 3.97 in June and 4.91 in July — not a good trend as he gets his 1st start of August.

Run line/Against the spread

PASS.

I’m going to keep my bet to the moneyline.

Over/Under

BET OVER 7.5 (-105).

It’s hard to ignore the trends with this one. These 2 teams have gone Over in their last 5 head-to-head meetings, including the 1st 2 games of this series. The Cardinals have also been Over in 5 straight games.

The Over has hit in 5 of Gibson’s last 6 starts, while it hit in 3 of Taillon’s last 5.

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