Sweet 16 first look: Duke vs. Houston odds, lines and trends

What you need to know: NCAA Tournament early look at Friday’s Duke vs. Houston Sweet 16 odds.

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The 4th-seeded Duke Blue Devils (26-8) meet the No. 1 seed Houston Cougars (32-4) Friday in a Sweet 16 matchup at American Airlines Center in Dallas. Tip-off is scheduled for 9:39 p.m. ET (CBS). Below, we look at Duke vs. Houston odds from BetMGM Sportsbook before making our expert college basketball picks and predictions.

Duke, No. 14 in the USA TODAY Sports Coaches Poll, has had a bit of a cakewalk thus far in the tourney with a 64-47 win over Vermont in the opening round and a 93-55 monstrosity over James Madison in the 2nd round. G Jared McCain led the way against JMU with 30 points on 8-of-11 from downtown, the most 3-pointers in school history in an NCAA Tournament game. He’s shooting the 3-ball at a 58.8% clip (10 for 17) in the tourney.

Houston, No. 2 in the USA TODAY Sports Coaches Poll, had to grind out an overtime win with a 100-95 final over Texas A&M Sunday night in the round of 32. Several key players fouled out, but the Cougars were able to hit enough free throws to hold off the Aggies. G Jamal Shead had 21 points and 10 assists while logging 45 minutes. The Cougars had an easier time with 16-seeded Longwood in a 86-46 opening-round victory.

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Duke vs. Houston odds

Provided by BetMGM Sportsbook’s; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:53 a.m. ET.

  • Moneyline (ML): Duke +150 (bet $100 to win $150) | Houston -185 (bet $185 to win $100)
  • Against the spread (ATS): Duke +3.5 (-105) | Houston -3.5 (-115)
  • Over/Under (O/U): 134.5 (O: -105 | U: -115)

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2023-24 betting stats (includes postseason)

Source: Covers.com

  • ML: Duke 26-8 | Houston  32-4
  • ATS: Duke 20-14 | Houston 17-17-2
  • O/U: Duke 13-21 | Houston 16-20

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Duke vs. Houston head-to-head

This will be the 1st-ever meeting between the schools in men’s basketball.

Duke went 2-3 against ranked opponents this season. G Jeremy Roach left the last game briefly after injuring his left pinkie. He returned 2 minutes later with his fingers wrapped. The Dukies were upended in the 2nd round last year 65-52 by Tennessee.

The Cougars were 6-2 against ranked foes this year. They made it to the Sweet 16 last year before falling 89-75 to the Miami Hurricanes. Houston’s campus is just 3 hours away from this venue, and they’ll have that advantage with the crowd.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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