Tampa Bay Buccaneers at Buffalo Bills odds, picks and predictions

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The Tampa Bay Buccaneers (3-3) and Buffalo Bills (4-3) meet for Thursday Night Football in Week 8 at Highmark Stadium. Kickoff is scheduled for 8:15 p.m. ET (Prime Video). Below, we analyze FanDuel Sportsbook’s lines around the Buccaneers vs. Bills odds, and make our expert NFL picks and predictions.

The Buccaneers are coming off a disappointing 16-13 setback at Raymond James Stadium in Tampa against the division rival Atlanta Falcons. The offense has had a power outage in the past 2 games, totaling just 19 points across the past 2 losses, spoiling a tremendous defensive effort.

Tampa has allowed just 18.0 PPG in the past 2 games, and the Bucs are allowing just 17.4 PPG overall, cashing the Under in 5 of 6 outings to date.

The Bills will also be happy to get back in action with a quick turnaround. Buffalo was stunned 29-25 on the road against a bad New England Patriots team. The Bills have dropped 2 of the past 3 games overall, while failing to cash against the spread (ATS) in 3 in a row. The offense has dropped off significantly, averaging just 19.7 PPG in the past 3 games after going for 41.0 PPG in the previous 3 contests.

Tampa hasn’t faced an AFC opponent so far this season. Buffalo is 2-0 straight up (SU) and ATS against the NFC in 2023.

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Buccaneers at Bills odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 5:33 p.m. ET.

Moneyline (ML): Buccaneers +320 (bet $100 to win $320) | Bills -405 (bet $405 to win $100)
Against the spread (ATS): Buccaneers +8.5 (-110) | Bills -8.5 (-110)
Over/Under (O/U): 42.5 (O: -115 | U: -105)

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Buccaneers at Bills key injuries

Buccaneers

OG Matt Feiler (knee) out
WR Chris Godwin (neck) questionable
QB Baker Mayfield (knee) questionable
S Kaevon Merriweather (ankle) out
DT Vita Vea (groin) questionable

Bills

TE Dawson Knox (wrist) out
LB Von Miller (knee) available
TE Quintin Morris (ankle) out
DT Ed Oliver (toe) questionable
DT Jordan Phillips (back) available
LB Baylon Spector (hamstring) out

Buccaneers at Bills picks and predictions

Prediction

Bills 23, Buccaneers 18

Moneyline

The Bills (-405) will cost you more than 4 times your potential return, and that’s risky business. Yes, Buffalo will be angry after a stunning loss against 1 of the worst teams in the NFL last weekend. However, the Bills offense, which has been struggling lately, faces a stiff test against one of the better defenses in the NFC.

PASS, and focus on the spread instead.

Against the spread

The BUCCANEERS +8.5 (-110) were my initial lean, but Mayfield was limited in practice. If he is ruled out, and backup QB Blaine Gabbert is entrusted with the start, then it’s all-in on the Bills -8.5 (-110). The line is likely to shift dramatically, too. Mayfield could very well be a game-time decision, as he tests his knee in pregame warmups, so be careful.

Over/Under

UNDER 42.5 (-105) is worth playing lightly, but again, be careful.

The Bills defense was dinged for 29 points by a shaky Patriots defense, so even the Bucs could get loose for some points here. That’s not expected, however. And the Bills offense has really had its issues lately, and that isn’t likely to be ironed out on a short week against a very good defensive unit.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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