Seattle Mariners at San Diego Padres odds, picks and predictions

Analyzing Wednesday’s Seattle Mariners at San Diego Padres odds and lines, with expert MLB picks, predictions and best bets.

The Seattle Mariners (30-30) and the San Diego Padres (28-33) wrap up a 2-game interleague series Wednesday at Petco Park. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Mariners vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Mariners lead 1-0; Mariners won 2022 series 3-1

The Mariners posted a 4-1 victory in Tuesday’s interleague series opener behind RHP Logan Gilbert. The game was still in question until the top of the 8th inning before the M’s tacked on a pair of insurance runs to put a bow on the scoring. OFs Teoscar Hernandez and Julio Rodriguez each had solo home runs and 2-hit games.

The Padres have alternated losses and wins in each of the past 9 games. San Diego’s offense has been limited to a single run in 4 of its last 7 contests, with the Under unsurprisingly going 6-1 during that stretch.

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Mariners at Padres projected starters

RHP George Kirby vs. RHP Michael Wacha

Kirby (5-4, 3.04 ERA) makes his 12th start. He has a 1.01 WHIP, 0.8 BB/9 and 7.4 K/9 in 71 innings.

  • Last start: No-decision, 8 IP, 0 ER, 3 H, 0 BB, 7 K in a 1-0 home win vs. the New York Yankees last Wednesday
  • 2023 road splits: 2-2, 2.34 ERA (34 2/3 IP, 9 ER) with 4 BB, 25 K and a .233 opponent batting average (OBA) in 5 starts with 1 CG

Wacha (5-2, 3.48 ERA) makes his 12th start. He has a 1.15 WHIP, 2.8 BB/9 and 8.3 K/9 in 62 innings.

  • Last start: Loss, 4 2/3 IP, 2 ER, 3 H, 5 BB, 8 K in a 2-1 home loss vs. the Chicago Cubs Friday
  • 2023 home splits: 3-2, 3.44 ERA (34 IP, 13 ER – 4 HR) with a .222 OBA in 6 starts

Mariners at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:48 a.m. ET.

  • Moneyline (ML): Mariners +100 (bet $100 to win $100) | Padres -120 (bet $120 to win $100)
  • Run line (RL)/Against the spread (ATS): Mariners -1.5 (+165) | Padres +1.5 (-200)
  • Over/Under (O/U): 7.5 (O: -120 | U: +100)

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Mariners at Padres picks and predictions

Prediction

Mariners 3, Padres 2

Moneyline

The MARINERS (+100) are a solid play at even money as they look to pull off the 2-game road sweep.

Seattle has won 5 straight games inside the AL West while cashing in 4 of the past 5 interleague games against a right-handed starting pitcher.

The Padres have managed to win just 3 of their last 10 games at home while going 2-5 in the previous 7 vs. righties.

Run line/Against the spread

The Padres +1.5 (-200) will cost you 2 times your potential return if you need a little insurance and do not like them straight up. I know I sure do not.

San Diego is just 1-9 in the past 10 tries in Game 2 of a series and is just 2-7 in the past 9 interleague outings.

PASS.

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Over/Under

The UNDER 7.5 (+100) might be the best play on the board in this matinee affair.

The Under cashed on Tuesday, and it is 5-1 in the past 6 for Seattle against NL West foes. The Under is 4 straight against teams with a losing record.

The Under has cashed in 20 of the past 26 games at Petco Park while going 19-6-2 in the previous 27 interleague contests. The Under is also 11-1-1 in the past 13 interleague battles at Petco Park.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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