The Notre Dame Fighting Irish (0-0) and Ohio State Buckeyes (0-0) tangle in the feature game of the college football Week 1 schedule. The Irish and Buckeyes will kick things off Saturday at 7:30 p.m. ET (ABC) at venerable Ohio Stadium in Columbus. Below, we analyze Tipico Sportsbook‘s lines around the Notre Dame vs. Ohio State odds; check back for our college football picks, predictions and bets.
Notre Dame ranked 20th in scoring (35.2 points per game) and 15th in scoring defense in a 2021 season that saw it go 11-2. ND lost to Cincinnati in the regular season and Oklahoma State in the Fiesta Bowl. The Irish open this season with a new coach as former Ohio State LB Marcus Freeman takes over for Brian Kelly, who led ND from 2010-21 before leaving for LSU.
Ohio State also went 11-2 in 2021. The Buckeyes suffered regular-season losses to Oregon and Michigan. QB C.J. Stroud returns as the signal caller for an OSU offense which last year led the nation in scoring at 45.7 PPG.
Notre Dame is No. 5 and Ohio State is No. 2 in the AFCA Coaches Poll powered by USA TODAY Sports.
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Notre Dame at Ohio State odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 6:33 p.m. ET.
- Money line: Notre Dame +550 (bet $100 to win $550) | Ohio State -850 (bet $850 to win $100)
- Against the spread (ATS): Notre Dame +17.5 (-108) | Ohio State -17.5 (-112)
- Over/Under (O/U): 58.5 (O: -110 | U: -110)
2021 betting stats
- ML: Notre Dame 11-2 | Ohio State 11-2
- ATS: Notre Dame 9-4 | Ohio State 7-6
- O/U: Notre Dame 7-6 | Ohio State 8-5
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Notre Dame vs. Ohio State head-to-head
The ND-OSU series dates back to 1935, but the 2 Midwest powers have met just 6 times all time. The Scarlet and Gray have won the last 4 of those 6 meetings in 1995, 1996, 2006, and 2016. The 2006 and 2016 meetings were in bowl games.
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