The Green Bay Packers and San Francisco 49ers meet in their preseason opener Friday. Kickoff from Levi’s Stadium for 8:30 p.m. ET (NFL Network). Below, we analyze Tipico Sportsbook‘s lines around the Packers vs. 49ers odds, and make our best NFL picks, predictions and bets.
The Packers will have their starting offensive line in action Friday, although MVP QB Aaron Rodgers will not play. Backup QB Jordan Love is expected to draw the start and will likely play plenty.
The 49ers might potentially start QB Nate Sudfeld, with former Iowa State product QB Brock Purdy as the backup. If new starter QB Trey Lance does play, it likely will be a cameo, and the team is unlikely to use QB Jimmy Garoppolo and risk a potential injury that would crush his possible trade value. WR/RB Deebo Samuel is also unlikely to suit up.
Packers at 49ers odds
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 3:41 p.m. ET.
- Money line (ML): Packers +115 (bet $100 to win $115) | 49ers -140 (bet $140 to win $100)
- Against the spread (ATS): Packers +2.5 (+100) | 49ers -2.5 (-120)
- Over/Under (O/U): 33.5 (O: -103 | U: -117)
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Packers at 49ers picks and predictions
Prediction
Packers 19, 49ers 13
Money line
The PACKERS (+115) are a value play on the road in their opener, as Love is a talented player who should be able to run the offense well in his time on the field. The 49ers are likely to have plenty of star players on the offensive side of the football resting, while the Pack will have most starters going.
Against the spread
The PACKERS +2.5 (+100) are an okay play at even-money, although my preference would be playing them straight up for the better payout. I don’t expect to see Lance play for the 49ers, and Jimmy G is unlikely to play, too. If it’s Sudfeld and Purdy handling the offense, it won’t end well for the home side.
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Over/Under
The UNDER 33.5 (-117) is the play. The Packers defense is nasty, and they’re likely to be facing a third- and fourth-string quarterback. The 49ers will struggle to put points on the board. The first preseason game is traditionally low-scoring, and these teams will give the Under bettors what they want.
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