The San Francisco 49ers (6-5) are on the road against the Seattle Seahawks (3-8) in Week 13 for a classic NFC West rivalry game. Kickoff is 4:25 p.m. ET at Lumen Field. Below, we look at the 49ers vs. Seahawks odds and lines, and make our best NFL picks, predictions and bets.
The 49ers have won three games in a row and four of their last five. They have scored 30 or more points while averaging 170 rushing yards across the four victories. Their one hiccup in the last five was a 31-17 loss to the Cardinals where they only mustered 39 rushing yards.
The Seahawks are a mess. They have lost three in a row and six of their last seven games. Since QB Russell Wilson returned from injured reserve they have scored a total of 28 points combined in three games. Wilson still has not won a home game this season.
49ers at Seahawks odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 8:30 p.m. ET.
- Money line: 49ers -175 (bet $175 to win $100) | Seahawks +140 (bet $100 to win $140)
- Against the spread (ATS): 49ers -3.5 (+100) | Seahawks +3.5 (-120)
- Over/Under (O/U): 45.5 (O: -108 | U: -112)
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49ers at Seahawks key injuries
49ers
- LB Dre Greenlaw (groin) out
- WR Deebo Samuel (groin) out
- RB Trey Sermon (ankle) out
- LB Fred Warner (hamstring) doubtful
- LB Marcell Harris (concussion) questionable
Seahawks
- G Damien Lewis (elbow) doubtful
- RB Rashaad Penny (hamstring) questionable
- RB Alex Collins (abdomen) questionable
- RB Travis Homer (calf) questionable
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49ers at Seahawks odds, lines, predictions and picks
Prediction
Seahawks 24, 49ers 23
Money line
Wilson’s finger injury was supposed to take four to eight weeks to recover and we enter the seventh week since he suffered the injury. It’s been clear that he’s not been 100% in the three games since he’s returned.
However, even with the struggles at home this season, the Seahawks beat the 49ers once this season and have done so 14 of the last 16 times they have played each other.
Rivalry games are always weird. With Samuel out and their linebackers banged up, this is the perfect week for an upset.
Take the SEAHAWKS (+140).
Against the spread
The Seahawks are 5-6 ATS this season but have failed to cover the spread in the three games since Wilson’s return.
The 49ers started the year 1-5 ATS but are 4-1 ATS in their last five games.
However, expecting the outright Seattle win, take the SEAHAWKS +3.5 (-120).
Over/Under
The Seahawks have only had one game this season hit the Over, an overtime game in Week 2.
The 49ers have had four of their last six games go Over the projected total.
This is the game the Seahawks come alive a little.
Take OVER 45.5 (-108).
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