San Diego Padres at San Francisco Giants odds, picks and prediction

Analyzing Saturday’s San Diego Padres at San Francisco Giants odds and lines, with expert MLB picks and predictions.

The San Diego Padres (78-82) face the San Francisco Giants (106-54) in the second game of their final three-game series of the season. First pitch is 4:05 p.m. ET Saturday at Oracle Park. Let’s analyze the lines around the Padres vs. Giants odds with MLB picks and predictions.

Padres RHP Joe Musgrove (11-9, 3.22 ERA) makes his 31st start and 32nd appearance. He has a 1.10 WHIP, 2.8 BB/9 and 10.2 K/9 through 176 1/3 IP.

  • The Padres are 1-3 in his four previous starts against the Giants this season.
  • Needs just 1 strikeout to reach 200 in a season for the first time in his career.

Giants RHP Kevin Gausman (14-6, 2.87 ERA) makes his 33rd start. He has a 1.04 WHIP, 2.4 BB/9 and 10.8 K/9 through 185 IP.

  • Has already set career-bests in ERA, strikeouts and WHIP.
  • The Giants are 4-1 in his five starts against the Padres this season.

Padres at Giants odds, lines, picks and prediction

MLB odds provided by Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 10:45 a.m. ET.

  • Money line: Padres +140 (bet $100 to win $140) | Giants -175 (bet $175 to win $100)
  • Against the spread/ATS: Padres +1.5 (-150) | Giants -1.5 (+122)
  • Over/Under: 7.5 (O: -130 | U: +105)

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Prediction

Giants 5, Padres 3

Money line (ML)

The Giants shut out the Padres 3-0 in the series opener on Friday and have won seven games in a row. They have 22 wins in their last 27 games and can clinch the NL West with just one more victory. San Francisco has won three of its last four against San Diego.

The Padres are reeling to end the season. They have lost seven straight and have only three wins in their last 20 games, although all three of those games were against the Giants. San Diego is 7-10 against San Francisco this season.

Take the GIANTS (-175).

Run line/Against the spread (ATS)

The Padres covered the spread in only two of their last 10 games. They are 74-86 ATS overall and 39-40 ATS on the road. Six of their last eight losses have come by at least 2 runs.

16 of the Giants’ last 22 wins have been by at least two runs. They are No.1 in baseball with a 97-63 ATS record and will be focused on getting that one final, clinching win today.

Take the GIANTS -1.5 (+122).

Over/Under (O/U)

11 of the 17 games between the clubs had totals of 8 or more runs.

13 of Gausman’s last 14 starts had totals of 8 or more runs.

Take OVER 7.5 (-130).

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