The San Diego Padres (78-81) open their final series of the year against the NL West-leading San Francisco Giants (105-54) Friday. First pitch is at 9:45 p.m. ET at Oracle Park. Let’s analyze the lines around the Padres vs. Giants odds with MLB picks and predictions.
Padres RHP Pedro Avila is making his first MLB start of the year and only the second start of his career. He appeared in 36 games, starting 11, between Double-A San Antonio and Triple-A El Paso. He was 2-4 with a 4.22 ERA, 1.35 WHIP, 4.3 BB/9 and 9.9 K/9 through 74 2/3 IP.
- His only other major league appearance was in 2019. He had a no-decision in a 7-6 win over the Arizona Diamondbacks and pitched 5 1/3 innings, allowing only 1 run on 4 hits.
- He is the Padres’ No. 21-ranked prospect.
Giants RHP Anthony DeSclafani (12-7, 3.26 ERA) makes his 31st start. He has a 1.10 WHIP, 2.3 BB/9 and 8.2 K/9 through 162 2/3 IP.
- This will be his fifth start of the year against the Padres. He is 1-1 with a 3.13 ERA and the Giants are 3-1 in those games.
- The Giants are 20-10 in his starts and have won four of his last five outings.
Padres at Giants odds, lines, picks and prediction
MLB odds provided by Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 6:15 p.m. ET.
- Money line: Padres +175 (bet $100 to win $175) | Giants -220 (bet $220 to win $100)
- Against the spread/ATS: Padres +1.5 (-115) | Giants -1.5 (-105)
- Over/Under: 8.5 (O: -130 | U: +105)
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Prediction
Giants 7, Padres 5
Money line (ML)
The Padres have lost six games in a row and have only one win in their last 12 games. They are 7-9 against the Giants this season and their three wins over the Giants are their only wins in their last 19 games. They have only 11 wins since Aug. 11.
The Giants have won six games in a row and eight of their last nine, holding a two-game lead over the Los Angeles Dodgers in the NL West with three games to play. With the division still up for grabs and the Padres struggling and with nothing to play for other than pride, they are a bad bet this weekend.
Take the GIANTS (-220).
Run line/Against the spread (ATS)
The Padres are only 7-12 ATS in their last 19 games. Ten of their last 16 losses were by at least 2 runs. They are 39-39 ATS on the road.
Seven of the Giants’ last 11 wins were by at least 2 runs. They have the best ATS record in the majors at 96-63 ATS and are No. 3 at home at 42-36 ATS.
Take the GIANTS -1.5 (-105).
Over/Under (O/U)
Fourteen of the last 20 games for the Padres had a total of 9 or more runs.
Seventeen of the Giants’ last 23 games finished with a total of at least 9 runs.
Half of the 16 games between the two teams had a total of 9 or more, but those eight came in the last 10 games against one another.
Take OVER 8.5 (-130).
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