Tough mid-season
The Bills once again have a tough middle-part of their schedule. The toughest might be Week 6 to Week 10. The Bills start that with their short week against the Chiefs at home, then Buffalo travels out to New York to face the Jets, who will be an improved team themselves.
Buffalo does have that back-to-back slate at home in Weeks 8 and 9, but tough opponents in the Patriots and the Seahawks. No Tom Brady, but the Pats are still a great defense. Russell Wilson is also pretty awesome at quarterback for the Seahawks. This stretch rounds out with a long cross-country visit to the Cardinals in the desert. The Bills need to handle their business in this stretch.