The 49ers offense struggled badly in their first matchup with the Seahawks. They were without a couple key players, the offensive line struggled, and Jimmy Garoppolo had his worst game of the year.

Another showing like the one they had in Week 10 could mean a runaway win for the Seahawks. These three players will be big difference-makers for San Francisco in their attempt to avoid another letdown against Seattle:

QB Jimmy Garoppolo

Garoppolo was bad against Seattle in their first meeting, and could’ve been worse had the Seahawks defense not dropped a couple interceptions. It wasn’t all his fault, but now he steps into perhaps the most hostile environment in the NFL at CenturyLink Field. We’ve seen Garoppolo play well in the Superdome – another raucous road environment – but how he responds in his first trip to Seattle will be the biggest key for the 49ers’ offense.