Offensive Line (9)
| Pos. | Starter | Backup |
| LT | Anthony Castonzo | Le’Raven Clark |
| LG | Quenton Nelson | Jake Eldrenkamp |
| C | Ryan Kelly | Javon Patterson |
| RG | Mark Glowinski | Danny Pinter* |
| RT | Braden Smith | — |
Analysis: With their starters intact for the third consecutive season, the Colts will boast one of the best offensive lines in football. Castonzo returns on a fresh two-year deal to anchor the blindside for Philip Rivers. The rest of the room won’t have many question marks leading up to the season. Clark was re-signed on a one-year deal basically out of necessity and because he has experience in the system. Patterson was a seventh-round pick in 2019 who tore his ACL in the spring, missing his entire rookie campaign. He’s likely the backup to Kelly. The interesting addition is the fifth-round pick in Pinter. Uber-athletic and highly intelligent, the Colts wanted to trade up for the Ball State product. He can work at tackle, guard and center, giving the Colts some great versatility. Chris Ballard mentioned Pinter will most likely work at guard and center.
Notable cuts: None