WATCH: Cardinals vs. 49ers Week 1 video preview

Check out what the big storylines are for the Week 1 matchup.

The Arizona Cardinals and San Francisco 49ers kick off their season against one another in Santa Clara in Week 1 of the 2020 NFL season.

What is there to know about this matchup in the above video preview?

The 49ers have a young receiving corps and no longer have Emmanuel Sanders, who was a major part of one of the 49ers’ wins over Arizona in 2019.

The Cardinals’ defensive secondary is mainly the same as it was from last season and it was the worst in the league, but additions to the front seven should help.

All three panelists predict a 49ers win over the Cardinals by a slim margin.

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Listen to the latest from Cards Wire’s Jess Root on his podcast, Rise Up, See Red. Subscribe on Apple podcasts or Spotify.

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and

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