WATCH: Auburn Tigers At Penn State Nittany Lions – Key Facts, Stats

The only 2021 regular-season matchup between SEC and Big Ten teams takes place in Happy Valley between Penn State and Auburn.

The only regular-season matchup in 2021 between SEC and Big Ten teams is a special occasion. The game, featuring the No. 22 Auburn Tigers visiting the No. 10 Penn State Nittany Lions, will be getting the ESPN College GameDay treatment, and it has also been designated for a Whiteout.
Auburn finished its past two seasons with bowl losses to Big Ten teams (Minnesota and Northwestern). Penn State, whose most recent SEC encounter was a bowl loss to Kentucky at the end of the 2018 season, is favored in this one. Go to Tipico Sportsbook for the most updated odds:

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