The Washington Commanders (7-6-1) are on the road in Week 16 to take on the NFC West champion San Francisco 49ers (10-4). They play Saturday afternoon at 4:05 p.m. ET at Levis Stadium in Santa Clara (CBS). Below, we analyze Tipico Sportsbook’s lines around the Commanders vs. 49ers odds, and make our expert NFL picks and predictions.
The Commanders lost to the New York Giants 20-12 last Sunday night at home as 4.5-point favorites. Their last 2 games were against the Giants. They won 3 in a row before that and currently are the No. 7 seed in the NFC.
The 49ers clinched the NFC West title with a 21-13 win over the Seattle Seahawks in Week 15 as 3-point favorites. They have won 7 games in a row.
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Commanders at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:57 a.m. ET.
- Moneyline (ML): Commanders +250 (bet $100 to win $250) | 49ers -300 (bet $300 to win $100)
- Against the spread (ATS): Commanders +6.5 (-109) | 49ers -6.5 (-111)
- Over/Under (O/U): 37 (O: -115 | U: -105)
Commanders at 49ers key injuries
Commanders
- OL Saahdiq Charles (concussion) out
- S Kamren Curl (ankle) questionable
- CB Benjamin St-Juste (ankle) questionable
49ers
- QB Jimmy Garoppolo (foot) out
- DL Kevin Givens (knee) out
- WR Deebo Samuel (ankle, knee) out
- CB Charvarius Ward (concussion) questionable
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Commanders at 49ers picks and predictions
Prediction
49ers 24, Commanders 10
Moneyline
The Commanders (+250) have played well on the road this season going 4-2-1, but face a 49ers team that is 6-1 at home. Washington has scored no more than 20 points in their last 3 games and face the league’s No. 1 defense in yards and points allowed.
The 49ers (-300) are riding a seven-game winning streak and have averaged 29.7 points a game over the last 3 weeks.
They should take care of business at home but the line doesn’t make it worth a wager on the moneyline.
PASS.
Against the spread
The Commanders are 7-6-1 ATS this season, matching their win-loss record.
The 49ers are 9-5 ATS, but have won each of their last 5 games by no fewer than 8 points.
BET 49ERS -6.5 (-111).
Over/Under
The projected total is low but both teams’ last game stayed under that total.
The 49ers have allowed an average of 11.0 points per game in their 7-game winning streak. The Commanders have not allowed more than 21 points in their last 10 games.
BET UNDER 37 (-105).
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