The No. 10 Wake Forest Demon Deacons (6-1, 2-1 ACC) and Louisville Cardinals (4-3, 2-3) meet Saturday in an ACC tussle at Cardinal Stadium. Kickoff is scheduled for 3:30 p.m. ET (ACC Network). Below, we analyze Tipico Sportsbook‘s lines around the Wake Forest vs. Louisville odds, and make our expert college football picks and predictions.
Wake Forest heads into this game with a 3-game win streak in tow, and its recent wins have been dominant. WFU downed Boston College 43-15 as a 20-point favorite last Saturday. The Deacons have outscored opponents by a combined score of 119-46 over their win streak.
The Cardinals have won 3 of their last 4 games, straight-up and against the spread. Louisville is at home for a 2nd straight week after prevailing over Pittsburgh 24-10 and covering as a 1-point favorite last Saturday. The Cards are facing their first ranked foe since losing to then-No. 24 Wake Forest 37-34 on Oct. 2, 2021.
Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.
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Wake Forest at Louisville odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 11:49 a.m. ET.
- Moneyline: Wake Forest -170 (bet $170 to win $100) | Louisville +135 (bet $100 to win $135)
- Against the spread (ATS): Wake Forest -3.5 (-107) | Louisville +3.5 (-115)
- Over/Under (O/U): 62.5 (O: -120 | U: -105)
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Wake Forest at Louisville picks and predictions
Prediction
Wake Forest 31, Louisville 30
Moneyline
Too much juice to consider the lean side which is Louisville. PASS.
Against the spread
Louisville has been terrific in red-zone defense, and its pass defense is a good fit for what the Demon Deacons do best.
Perhaps WFU gets caught looking ahead to Nov. 5 and Nov. 12 games against NC State and North Carolina.
TAKE THE CARDINALS +3.5 (-115).
Over/Under
The last 3 Wake Forest games have hit the Under, and that would be the play here at the right number.
Louisville has a solid pass defense, and both teams can cause enough havoc to keep the offenses off schedule. Wake can sling it around on offense, but the Deacons will run the ball, and they may want to keep some looks under wraps before upcoming games against UNC and NCSU.
Keep an eye on this total: be ready to pounce on the Under 63.5. Otherwise, PASS.
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