USA TODAY Sports Network’s NFL Week 16 game previews, predictions

The USA TODAY Sports Network previews Week 16 in the NFL, with Bills-Patriots, Cowboys-Eagles and Packers-Vikings leading the schedule.

Los Angeles Rams at San Francisco 49ers

San Francisco 49ers Los Angeles Rams
Robert Hanashiro-USA TODAY Sports

TV: 8:15 p.m. ET Saturday, NFL Network

Records: Rams 8-6, 49ers 11-3

Line: 49ers by 6½

Satellite radio: Rams feed on Sirius 82 (streaming 817), 49ers feed on Sirius 83 (streaming 827)

Rams’ keys: Getting out to a fast start and playing from ahead allows DT Aaron Donald to wreak havoc on a San Francisco offensive line that’s starting its backup center. Stifling defense was the Rams’ formula for beating the 49ers in their Week 6 matchup.

49ers’ keys:  The emergence of WR Deebo Samuel and the arrival of WR Emmanuel Sanders have helped QB Jimmy Garoppolo.

Who wins? The Rams’ recent offensive resurgence should make them more effective than they were in their first game against the 49ers, but their inability to block San Francisco’s dynamic defensive front will be the difference. 49ers 23, Rams 17

Kyle Madson