USA TODAY Sports Network’s NFL Week 16 game previews, predictions

The USA TODAY Sports Network previews Week 16 in the NFL, with Bills-Patriots, Cowboys-Eagles and Packers-Vikings leading the schedule.

Buffalo Bills at New England Patriots

New England Patriots Buffalo Bills
Mark Konezny-USA TODAY Sports

TV: 4:30 p.m. ET Saturday, NFL Network

Records: Bills 10-4, Patriots 11-3

Line: Patriots by 6½

Satellite radio: Bills feed on Sirius 82 (streaming 803), Pats feed on Sirius 83 (streaming 820)

Bills’ keys: Maintain long and efficient possessions by featuring RB Devin Singletary against New England’s run defense. The Bills’ defense, meanwhile, needs to play only slightly better than it did in these teams’ first matchup, which the Patriots won 16-10.

Patriots’ keys: QB Tom Brady must avoid turnovers, even if it means New England plays an ugly and boring brand of football. The Patriots wouldn’t mind featuring RB Sony Michel for the entire game.

Who wins? If this game were in Buffalo, the Bills might win. But … Patriots 17, Bills 10

Henry McKenna