UFC 250 predictions: Is anyone picking big underdog Felicia Spencer to upset dual champ Amanda Nunes?

Check out our staff members’ picks for UFC 250, featuring dual champ Amanda Nunes vs. featherweight challenger Felicia Spencer.

Nunes
vs.
Spencer
Assuncao
vs.
Garbrandt
Sandhagen
vs.
Sterling
Magny
vs.
Martin
O’Malley
vs.
Wineland
MMA Junkie readers’
consensus picks
2020: 46-32
nunes2020
Nunes
(75%)
garbrandt2020
Garbrandt
(54%)
sandhagen2020
Sandhagen
(53%)
magny2020
Magny
(76%)
omalley2020
O’Malley
(89%)
Nolan King
@mma_kings
2020: 58-20
nunes2020
Nunes
assuncao2020
Assuncao
sterling2020
Sterling
magny2020
Magny
omalley2020
O’Malley
Dan Tom
@DanTomMMA
2020: 57-21
nunes2020
Nunes
assuncao2020
Assuncao
sterling2020
Sterling
magny2020
Magny
omalley2020
O’Malley
Simon Samano
@SJSamano
2020: 55-23
nunes2020
Nunes
assuncao2020
Assuncao
sandhagen2020
Sandhagen
magny2020
Magny
omalley2020
O’Malley
Farah Hannoun
@Farah_Hannoun
2020: 55-23
nunes2020
Nunes
garbrandt2020
Garbrandt
sandhagen2020
Sandhagen
magny2020
Magny
omalley2020
O’Malley
Simon Head
@simonhead
2020: 54-24
trophy copy 2019 Champion*
nunes2020
Nunes
garbrandt2020
Garbrandt
sterling2020
Sterling
martin2020
Martin
omalley2020
O’Malley
Brian Garcia
@thegoze
2020: 54-24
trophy copy 2017 Champion
nunes2020
Nunes
assuncao2020
Assuncao
sterling2020
Sterling
magny2020
Magny
omalley2020
O’Malley
Ken Hathaway
@kenshathaway
2020: 53-25
trophy copy 2018 Champion
nunes2020
Nunes
assuncao2020
Assuncao
sandhagen2020
Sandhagen
magny2020
Magny
omalley2020
O’Malley
John Morgan
@MMAjunkieJohn
2020: 53-25
nunes2020
Nunes
garbrandt2020
Garbrandt
sterling2020
Sterling
martin2020
Martin
omalley2020
O’Malley
Mike Bohn
@MikeBohnMMA
2020: 53-25
trophy copy 2014 Champion
nunes2020
Nunes
garbrandt2020
Garbrandt
sterling2020
Sterling
magny2020
Magny
omalley2020
O’Malley
Danny Segura
@dannyseguratv
2020: 52-26
nunes2020
Nunes
assuncao2020
Assuncao
sandhagen2020
Sandhagen
magny2020
Magny
omalley2020
O’Malley
Dave Doyle
@davedoylemma
2020: 51-27
nunes2020
Nunes
assuncao2020
Assuncao
sandhagen2020
Sandhagen
magny2020
Magny
omalley2020
O’Malley
George Garcia
@MMAjunkieGeorge
2020: 48-30
nunes2020
Nunes
garbrandt2020
Garbrandt
sterling2020
Sterling
magny2020
Magny
omalley2020
O’Malley
Abbey Subhan
@kammakaze
2020: 44-34
nunes2020
Nunes
garbrandt2020
Garbrandt
sterling2020
Sterling
magny2020
Magny
omalley2020
O’Malley
Matt Erickson
@MMAjunkieMatt
2020: 33-45
spencer2020
Spencer
assuncao2020
Assuncao
sandhagen2020
Sandhagen
magny2020
Magny
wineland2020
Wineland

The UFC is back Saturday with an event headlined by arguably the greatest women’s fighter of all time.

UFC 250 takes place Saturday at the UFC Apex in Las Vegas. The main card airs on pay-per-view following prelims on ESPN and early prelims on UFC Fight Pass/ESPN+.

(Click here to open a PDF of the staff picks grid in a separate window.)

In the main event, women’s bantamweight and featherweight champion [autotag]Amanda Nunes[/autotag] (19-4 MMA, 12-1 UFC) puts her 145-pound title on the line for the first time against challenger [autotag]Felicia Spencer[/autotag] (8-1 MMA, 2-1 UFC). Nunes is the huge favorite at -650, and not surprisingly she’s a near-unanimous choice in the picks from our 14 editors, writers, videographers and radio hosts – only one of whom is picking Spencer in a major upset.

In the co-main event, [autotag]Raphael Assuncao[/autotag] (27-7 MMA, 11-4 UFC) takes on former bantamweight champion [autotag]Cody Garbrandt[/autotag] (11-3 MMA, 6-3 UFC) in a key contenders fight. Garbrandt is a slight favorite at -150, but it’s Assuncao with a slight 8-6 lead in the picks from our staff members.

Also on the main card, [autotag]Cory Sandhagen[/autotag] (12-1 MMA, 5-0 UFC) takes on [autotag]Aljamain Sterling[/autotag] (18-3 MMA, 10-3 UFC) in another important bantamweight bout. The fight is a virtual pick’em from the oddsmakers, and it’s close with our pickers, as well. Sterling has the edge at 8-6.

[autotag]Neil Magny[/autotag] (22-7 MMA, 15-6 UFC) is a -135 favorite against [autotag]Anthony Rocco Martin[/autotag] (17-5 MMA, 9-5 UFC) in a welterweight fight. But despite those close odds at the sports books, Magny has a huge 12-2 lead over Martin in our picks.

And to open the main card, [autotag]Sean O’Malley[/autotag] (11-0 MMA, 3-0 UFC) is the second biggest favorite on the card in his fight against former WEC bantamweight champ [autotag]Eddie Wineland[/autotag] (24-13-1 MMA, 6-7 UFC). With O’Malley a -550 favorite, only one of our pickers is taking Wineland to pull off what would be the biggest upset of his career.

In the MMA Junkie reader consensus picks, Nunes (75 percent), Garbrandt (54 percent), Sandhagen (53 percent), Magny (76 percent) and O’Malley (89 percent) are the choices.

Check out all the picks above.