Maui Ahuna, Griffin Merritt, Christian Scott and Charlie Taylor hit home runs for the Vols.
Aaron Combs (4-0) earned the win for Tennessee, pitching 0.2 innings. He recorded two strikeouts versus five batters.
Tennessee leads the all-time series versus Austin Peay, 22-5.
The Vols will next host Kentucky, Friday-Sunday, at Lindsey Nelson Stadium.
Friday’s series opener between the Vols and Wildcats is slated for 6:30 p.m. EDT (SEC Network+), while game No. 2 will take place at noon EDT on Saturday (SEC Network).
Sunday’s series finale is slated for 1 p.m. EDT (SEC Network+).
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Tennessee sixth-year head coach Tony Vitello met with media following the game. Vitello’s media availability can be watched below.