The 2021 NFL season begins Thursday, Sept. 9, and the quest for the 2022 Super Bowl begins. The Tampa Bay Buccaneers begin their title defense, while the Kansas City Chiefs seek to make it back to the big game for the third straight year. Below, we look at the odds to win the 2022 Super Bowl, with NFL picks, predictions and best bets.
The Cleveland Browns loaded up on defense in the offseason and the Los Angeles Rams upgraded at quarterback while returning the league’s No. 1 defense from 2020.
So who are the best bets for this season’s championship?
2022 Super Bowl picks
Odds via Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday, Aug. 31.
Kansas City Chiefs (+450)
Bet $100 to win $450
The Chiefs have been to the Super Bowl two years in a row and have the NFL’s best quarterback in Patrick Mahomes. He throws to TE Travis Kelce and WR Tyreek Hill, while second-year RB Clyde Edwards-Helaire is expected to have a greater role in 2021.
The Chiefs also remade their offensive line after Mahomes struggled to find time to throw in their Super Bowl loss to the Buccaneers.
Also see: Week 1 odds and lines
Tampa Bay Buccaneers (+600)
Bet $100 to win $600
They are the defending champions and have returned their entire starting lineup. Of course, repeat Super Bowl champions are rare, which makes this pick a bit risky.
The last team to repeat was the New England Patriots in 2004-2005. The quarterback then was Tom Brady, who is the Bucs’ quarterback now. So if anyone can do it, Brady can.
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Los Angeles Rams (+1200)
Bet $100 to win $1,200
The Rams had the No. 1 defense a year ago and just upgraded at quarterback by trading Jared Goff for Matthew Stafford. The Rams went to a Super Bowl with Goff and with an upgrade at quarterback, the offense should be great.
The defense, if it continues at its current level, will make the Rams very hard to beat.
Also see: Super Bowl LVI odds for all 32 teams
Cleveland Browns (+1300)
Bet $100 to win $1,300
Cleveland won 11 regular-season games and a playoff contest last season. They loaded up on defense in the offseason and will get WR Odell Beckham Jr. back for the 2021 campaign, making the offense even better.
There is no real weakness on this team, which feels weird to say about the historically inept Browns.
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Arizona Cardinals (+4000)
Bet $100 to win $4,000
This is a pick solely if you want to take a chance on a long shot. Of all the long shots, the Cardinals are appealing, as they just missed the playoffs last season and have a budding star at quarterback in Kyler Murray.
If he can take a step forward like Buffalo Bills QB Josh Allen did last year, the Cardinals will be incredibly exciting. They are better at almost every position, they have weapons on offense and a healthier, improved defense on paper. Of all the long shots, the Cardinals are the best pick to win Super Bowl 56.
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