USC at UCLA odds, picks and predictions

Analyzing Saturday’s USC at UCLA odds and lines, with college football expert picks, predictions and best bets.

The No. 6 USC Trojans (9-1, 7-1 Pac-12) take on the No. 16 UCLA Bruins (8-2, 5-2) Saturday at 8 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the USC vs. UCLA odds, and make our expert college football picks and predictions.

Ranking courtesy of AFCA Coaches Poll powered by USA TODAY sports

This will be the 92nd meeting between the 2 rivals and the 10th time when both teams are ranked. It’s 5-5 in those instances. During a dismal 2021 season for USC, the Bruins stomped the Trojans 62-33. USC won the previous year 42-38.

This game should be another classic. And another high-scoring affair.

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USC at UCLA odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 10:59  p.m. ET.

  • Moneyline (ML): USC -130 (bet $130 to win $100) | UCLA +110 (bet $100 to win $110)
  • Against the spread (ATS): USC -2 (-109) | UCLA +2 (-111)
  • Over/Under (O/U): 76.5 (O: -111 | U: -109)

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USC at UCLA picks and predictions

Prediction

USC 51, UCLA 45

Moneyline

PASS.

USC should win this game. Its number on the spread -109 pays better than taking them moneyline -130. I will save the juice and make a small parlay on the spread and total.

Against the spread

BET USC -2 (-109).

USC must win this game. UCLA wants to win this game. There is a difference.

QB Caleb Williams has dragged USC and its terrible defense to a 9-1 record this season. WRs Mario Williams and Jordan Addison have both missed time yet the Trojans still put up points.

UCLA is having its best season in a decade. This would be a wonderful way to finish it off, but the defense of the Bruins is as bad as the USC defense and just gave up 34 points at home to Arizona. Williams and company will score enough to cover these -2 numbers so I will take USC and lay the points.

Over/Under

BET OVER 76.5 (-111).

Remember what was said above about the defenses or lack thereof? It will allow anyone who wants a TD in this game to get 1. The winner of the game will be the team who makes more stops, or even 1 stop, of the other offense.

This game opened at 82 but has been bet down to 76.5. Even at 82, I may have taken it. But at 76.5 (-111) it is my favorite play in this game.

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