Arizona Diamondbacks at San Diego Padres odds, picks and best bets

Previewing Saturday’s Arizona Diamondbacks at San Diego Padres sports betting odds and lines, with MLB betting picks, tips and best bets.

The Arizona Diamondbacks try to avenge a 7-2 Opening Day loss in Game 2 of their season-opening series against the San Diego Padres Saturday at Petco Park. First pitch is set for 9:10 p.m. ET. We analyze the Diamondbacks-Padres MLB betting odds and lines, with betting picks and best bets around the matchup.

Diamondbacks at Padres: Projected starting pitchers

LHP Robbie Ray vs. RHP Dinelson Lamet

Ray: 12-8 over 33 2019 starts with a 4.34 ERA through 174 1/3 innings. Career-best 12.13 strikeouts per nine innings.

  • Suffered from a suppressed 75.1% left-on-base percentage and elevated 20% home run/fly ball ratio.
  • Struggled in the second half of the season and was much better at home in the desert.

Lamet: 4.07 ERA and 3-5 record over 73 innings and 14 starts.

  • Struck out 12.95 batters per nine with 3.70 walks after making his season debut in early July.
  • Was markedly worse at home with a 5.25 ERA compared to his 2.92 road rate.

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Diamondbacks at Padres: Key injuries

Visit sportsdata.usatoday.com to track all MLB injuries leading up to game time.

Diamondbacks

  • RP Silvino Bracho (elbow) out
  • RP Corbin Martin (elbow) out

Padres

  • SS Jorge Mateo (illness) out
  • RP Jose Castillo (back) out

Diamondbacks at Padres: Odds, lines, picks and betting tips

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at noon ET.

Prediction

Diamondbacks 6, Padres 4

Moneyline (ML)

Saturday’s line has been skewed by Friday’s lopsided result. The Diamondbacks enter Game 2 as +120 underdogs with the Padres priced as -134 favorites to start 2-0.

Lamet’s home splits in 2019 are rather worrisome and Ray’s K rate should be a big advantage against a young Padres lineup early in the season. The D-Backs recorded seven hits against the Padres’ eight in the series opener, as the majority of the damage came via the seven walks allowed by Arizona pitchers.

Bet the DIAMONDBACKS (+120) to pull even as a solid underdog value.

New to sports betting? A $10 bet on the Diamondbacks to win would return a profit of $12.

Run line/Against the spread (ATS)

The real money will be made on the moneyline for the Diamondbacks, but ARIZONA +1.5 (-189) can also be taken on the run line for a little insurance.

The D-Backs were fourth in baseball with a 90-72 ATS record in 2019, and they were 10-9 ATS against their National League West rivals.

Over/Under (O/U)

Take the OVER 8 (-110) in a weaker pitching matchup than we had Friday, when the two teams totaled nine runs. Both of Saturday’s starters can get into trouble and aren’t safe bets to go too deep into this game. The D-Backs used four relievers in the opener and San Diego used three.

Esten’s 2020 MLB betting record: 4-2

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