Tennessee Titans at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Tennessee Titans at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Tennessee Titans (1-4) and Buffalo Bills (4-2) meet in Week 7 Sunday. Kickoff from Highmark Stadium is set for 1:00 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Titans vs. Bills odds, and make our expert NFL picks and predictions..

The Titans remained winless at home after a 20-17 loss to the Colts, failing to cover as 2.5-point favorites, with the game hitting the under on a 41.5 total. Quarterback Will Levis struggled, throwing for just 95 yards with a touchdown and an interception. The bright spot was RB Tony Pollard, who rushed for 93 yards, including a 23-yard touchdown run. However, Pollard’s efforts weren’t enough to lift the Titans past their offensive struggles, as they fell short once again.

The Buffalo Bills ended their 2-game losing streak with a 23-20 win over division rival Jets, covering the 1-point spread as the game went over the 42 total. QB Josh Allen was efficient, completing 19 of 25 passes for 215 yards and 2 touchdowns. Rookie RB Ray Davis stepped up in place of the injured James Cook, racking up 152 total yards on 23 touches. The Bills also bolstered their offense with the addition of WR Amari Cooper.

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Titans at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 2:15 p.m. ET.

  • Moneyline (ML): Titans +380 (bet $100 to win $380) | Bills -500 (bet $500 to win $100)
  • Against the spread (ATS): Titans +9.5 (-110) | Bills -9.5 (-110)
  • Over/Under (O/U): 41 (O: -110 | U: -110)

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Titans at Bills key injuries

Titans

  • WR Treylon Burks (knee) out
  • DE Keondre Coburn (knee) out
  • LB Cedric Gray (shoulder) out
  • QB Will Levis (shoulder) questionable
  • CB L’Jarius Sneed (quad) questionable
  • RB Tyjae Spears (hamstring) out

Bills

  • RB Ray Davis (calf) questionable
  • S Mike Edwards (illness) questionable
  • RB Darrynton Evans (hamstring) doubtful

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Titans at Bills picks and predictions

Prediction

Bills 26, Titans 13

Moneyline

PASS.

No doubt in my mind that the Bills (-500) win this game and cover Sunday, which is why they are such heavy favorites. So, I’ll take my wager to the spread.

Against the spread

BET BILLS -9.5 (-110).

Sunday’s game at Highmark Stadium marks the first meeting between the Bills and Titans in over 2 years. Buffalo dominated their last matchup in Sept. 2022, winning 41-7, and has won 4 of the past 6 meetings, including consecutive home victories. While this matchup might look tough for Buffalo on paper, coming off a close Monday Night Football win over the Jets, their acquisition of Cooper provides a boost to their offense. The Bills have thrived against weaker opponents, and with Cooper in the mix, their passing attack should flourish.

The Titans face a tough challenge, particularly with their struggling passing game. Levis is questionable with a shoulder injury. Furthermore, he has the worst interception rate in the league and struggles to protect the ball, which could spell trouble against Buffalo’s solid pass defense. Tennessee’s road woes are also a concern, having averaged just 9.5 points per game during a 2-game losing streak at Highmark Stadium. While Buffalo has struggled to cover large spreads recently, the Titans’ offense lacks firepower to keep pace. Given Buffalo’s home dominance and Tennessee’s road struggles, I’m backing the Bills -9.5 to control this matchup, expecting a performance similar to their earlier blowout win over Jacksonville.

Over/Under

BET UNDER 41 (-110).

The Titans have struggled offensively, particularly in the passing game, with Levis managing only 3.8 yards per attempt in their recent loss to the Colts. Meanwhile, Tennessee’s defense has been a bright spot, allowing the fewest yards per attempt in the NFL, which could limit Allen and Buffalo’s passing attack.

The Bills’ defense has also been effective, ranking 9th in EPA per pass, with a strong secondary that could challenge the Titans’ struggling offense. With a tough road game in Seattle up next, Buffalo might lean on a run-heavy game plan to control the pace and limit scoring opportunities. Considering these factors, this game seems likely to be a slow-paced, defensive battle, making the Under 41 a good bet.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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