Syracuse at Clemson odds, picks and predictions

Analyzing Saturday’s Syracuse at Clemson odds and lines, with college football expert picks, predictions and best bets.

The No. 14 Syracuse Orange (6-0, 3-0 ACC) and the No. 5 Clemson Tigers (7-0, 5-0) play Saturday at Memorial Stadium. Kickoff is scheduled for noon ET (ABC). Below, we analyze Tipico Sportsbook‘s lines around the Syracuse vs. Clemson odds, and make our expert college football picks and predictions.

The Orange head south looking to stay unbeaten and climb to the top of the ACC Atlantic Division standings. Syracuse is coming off a 24-9 home win over NC State as a 3-point favorite last time out, moving to 5-1 ATS overall on the season.

The Tigers are not only 7-0 overall, and 5-0 inside the ACC, but they’re 4-0 in the Atlantic Division. A win here won’t quite clinch the division and punch their ticket to the ACC Championship Game, but it will move the Tigers much closer after having already topped Florida State, NC State and Wake Forest.

Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.

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Syracuse at Clemson odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 10:08 a.m. ET.

  • Moneyline (ML): Syracuse +440 (bet $100 to win $440) | Clemson -650 (bet $650 to win $100)
  • Against the spread (ATS): Syracuse +13.5 (-108) | Clemson -13.5 (-112)
  • Over/Under (O/U): 50.5 (O: -107 | U: -115)

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Syracuse at Clemson picks and predictions

Prediction

Clemson 30, Syracuse 20

Moneyline

Clemson (-650) will cost you over 6 times your potential return, and that’s just too much risk for not enough return. Syracuse usually plays the Tigers tough, so that’s even more of a problem.

AVOID.

Against the spread

SYRACUSE +13.5 (-108) heads into this one with a 5-1 ATS mark across the past 6 outings, while going 5-2 ATS in the past 7 on the road and 9-4 ATS in the previous 13 ACC games. Coach Dino Babers has this team playing well, RB Sean Tucker is a star in the making and WR Oronde Gadsden II can help spread the field.

This isn’t a boring Orange offense that has the tools to just hang for a half. Syracuse can go the whole 60 minutes and will give Clemson its most difficult test yet. If this game were in upstate New York, we might be considering an upset.

Over/Under

UNDER 50.5 (-115) is the lean here.

The Under has cashed in each of Syracuse’s past 4 ACC games and is 5-2 in its last 7 games overall.

The Over has hit in 4 of the last 5 games overall for Clemson, but the Under is 4-1-1 in its last 6 following a cover, and, more importantly, the Under has hit in 5 of the previous 6 meetings in this series.

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First look: Syracuse at Clemson odds and lines

Looking at Saturday’s Syracuse at Clemson college football odds, lines and trends. Here’s what you need to know.

The No. 14 Syracuse Orange (6-0, 3-0 ACC) and No. 5 Clemson Tigers (7-0, 5-0) meet Saturday at Memorial Stadium in Clemson, S.C. Kickoff is scheduled for noon ET (ABC). Below, we look at Syracuse vs. Clemson odds from Tipico Sportsbook; check back for all our college football picks and predictions.

The Orange moved to 6-0 with a 24-9 win over NC State last weekend at the JMA Wireless Dome. Syracuse is also 5-1 ATS, and the defense has allowed just 9 points in the past 2 games, while cashing the Under in 3 in a row.

The Tigers have scored 30 or more points in all 7 games this season, and Clemson’s high-octane attack will be the biggest challenge for the Syracuse defense yet. Clemson has covered each of the past 3 games, too.

Syracuse is No. 14 and Clemson is No. 5 in the AFCA Coaches Poll powered by USA TODAY Sports.

Stream select live college football games and full replays: Get ESPN+

Syracuse at Clemson odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 2:15 p.m. ET.

  • Moneyline (ML): Off the board.
  • Against the spread (ATS): Syracuse +13.5 (-108) | Clemson -13.5 (-112)
  • Over/Under (O/U): 51.5 (O: -115 | U: -107)

2022 betting stats

  • ML: Syracuse 6-0 | Clemson 7-0
  • ATS: Syracuse 5-1 | Clemson 4-3
  • O/U: Syracuse 2-4 | Clemson 4-3

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

Syracuse at Clemson head-to-head

The Tigers lead the all-time series 8-2, including victories in each of the past four matchups. Clemson eked out a 17-14 victory in Syracuse last season, while winning 47-21 in the most recent meeting at Death Valley Oct. 24, 2020.

Play our free daily Pick’em Challenge and win! Play now!

Want action on this game or any other NCAA football matchup? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:

Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

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