Seattle Seahawks vs. San Francisco 49ers odds predictions pick betting line spread

Seattle Seahawks at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Seattle Seahawks at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

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The Seattle Seahawks (1-0) visit the San Francisco 49ers (0-1) Sunday at Levi’s Stadium. Kickoff is at 4:05 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Seahawks vs. 49ers, and make our expert NFL picks and predictions.

After week 1 there are more questions surrounding these teams than answers. The 49ers came into a rainy Chicago and lost 19-10 to a Bears team that only managed 204 total yards. QB Trey Lance went 13-of-28 with a 50.3 passer rating. Backup QB Jimmy Garoppolo is looking like a better option each day.

The Seahawks pulled off an upset in what looked like a one-sided revenge game against the Denver Broncos. The Seahawks allowed 6.8 yards per play and put up just 5.2 themselves but somehow won. QB Geno Smith showed everyone why he beat out QB Drew Lock for the starting job, going 23-of-28 with 2 TDs and 0 INT.

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Seahawks at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:17 p.m. ET.

Money line (ML): Seahawks +350 (bet $100 to win $350) | 49ers -450 (bet $450 to win $100)
Against the spread (ATS): Seahawks +9.5 (-112) | 49ers -9.5 (-108)
Over/Under (O/U): 40.5 (O: -117 | U: -103)

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Seahawks at 49ers key injuries

Seahawks

S Jamal Adams (knee) out
CB Artie Burns (groin) questionable
CB Justin Coleman (calf) questionable

49ers

LB Dre Greenlaw (elbow) questionable
TE George Kittle (groin) questionable
RB Elijah Mitchell (knee) out – injured reserve

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Seahawks at 49ers picks and predictions

Prediction

49ers 13, Seahawks 9

Money line

There are reasons to like the 49ers, their defense allowed the 3rd fewest yards in 2021 and they start 2022 in the same fashion. Running back Jeff Wilson Jr. can fill in the role left by RB Elijah Mitchell‘s week 1 injury and they are prime for a comeback.

The Seahawks benefited from Denver’s 2 endzone fumbles and some atrocious coaching decisions to pull off a win last week. They can’t expect such luck each week. Smith is also poised for regression after a strong start.

However, the lines are a bit too juicy to risk on the 49ers after their week 1 debacle. It’s best to AVOID.

Against the spread

The Seahawks are 5-2 ATS in their last 7 games as underdogs. This line is huge and likely based on preseason expectations instead of how these teams played in their openers.

BET SEAHAWKS +9.5 (-112).

Over/Under

The Under is 5-1 in Seahawks’ last 6 games as road underdogs — and it’s not just Seattle that points to a low-scoring game. The 49ers have gone Under 4 straight times following an outright loss.

LEAN UNDER 40.5 (-103).

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Seattle Seahawks at San Francisco 49ers odds, picks and prediction

Analyzing Sunday’s Seattle Seahawks at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (2-1) and Seattle Seahawks (1-2) meet in Week 4 for an NFC West showdown. Kickoff is at 4:05 p.m. ET at Levi’s Stadium. Below, we look at the Seahawks vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.

The Seahawks lost back-to-back games after a season-opening win over the Indianapolis Colts. The issue has been defense, as Seattle allowed 33 points to the Tennessee Titans and 30 to the Minnesota Vikings. QB Russell Wilson has thrown 7 touchdown passes in three games without an interception.

The 49ers suffered their first loss of the season in Week 3, falling 30-28 to the Green Bay Packers on a last-second field goal after they had scored a go-ahead touchdown with under a minute left. The offense has been uneven, with 41 points in Week 1, only 17 in Week 2 and 28 in Week 3. The Niners have had defensive issues as well while allowing two of their three opponents to score 30 or more points.

Also see: Week 4 staff picks

Seahawks at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 5:40 p.m. ET.

Money line: Seahawks +125 (bet $100 to win $125) | 49ers -155 (bet $155 to win $100)
Against the spread (ATS): Seahawks +2.5 (+105) | 49ers -2.5 (-130)
Over/Under (O/U): 51.5 (O: -115 | U: -105)

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Seahawks at 49ers key injuries

Seahawks

WR Dee Eskridge (concussion) out
RB Rashaad Penny (calf) out
OT Brandon Shell (ankle) out
LB Benson Mayowa (neck) questionable

49ers

DT Javon Kinlaw (knee) questionable
RB Elijah Mitchell (shoulder) doubtful
DL Arik Armstead (adductor) questionable
DL Kevin Givens (ankle) out
RB JaMycal Hasty (ankle) out
CB Emmanuel Moseley (knee) questionable

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Seahawks at 49ers odds, lines, predictions and picks

Prediction

49ers 34, Seahawks 28

Money line

The Seahawks handled a Colts offense that has struggled this season but have not stopped anyone else. The 49ers have been very good offensively in two of three games.

The Seahawks are the only team in the division with a negative point differential but they won 13 of the last 15 games between the two teams.

San Francisco lost their home opener and will not want to drop its first two at home. QB Jimmy Garoppolo was 7-3 at home over the previous two seasons.

Take the 49ERS (-155).

Against the spread

Both teams are 1-2 ATS this season.

The 49ers’ twos wins this year were each by 6 or more points. The Seahawks have not covered the spread in a loss, although this is the first game in which they’ve been underdogs.

This is really a toss-up game but expecting a 49ers win, 2.5 points is too few to think the Seahawks would lose but cover.

Take the 49ERS -2.5 (-130).

Over/Under

Both teams have one game where they kept their opponent under 20 points but their other two opponents scored at least 30.

Both offenses are explosive and both defenses have shown they can be scored on.

This will be a shootout. Take OVER 51.5 (-115).

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Seattle Seahawks at San Francisco 49ers odds, picks and prediction

Previewing the Seattle Seahawks at San Francisco 49ers Week 17 betting odds and lines, with NFL betting picks, tips and predictions.

The Seattle Seahawks (11-4) have already locked up the NFC West and will simply be playing for playoff positioning in Week 17 when they visit the San Francisco 49ers (6-9). Sunday’s kickoff is set for 4:25 p.m. ET at the 49ers’ temporary home of State Farm Stadium in Glendale, Ariz. Below, we preview the Seahawks-49ers betting odds and lines and make our NFL picks and predictions.

Seahawks at 49ers: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at noon ET.

Money line: Seahawks -295 (bet $295 to win $100) | 49ers +240 (bet $100 to win $240)
Against the spread/ATS: Seahawks -6.5 (-110) | 49ers +6.5 (-110)
Over/Under: 45.5 (O: -115 | U: -105)

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Seahawks at 49ers: Game notes

The 49ers are 1-3 in their last four games, and just 2-6 in their last eight.
The Seahawks won their first meeting with the 49ers 37-27 in Week 8. They covered a 1-point spread.
The Seahawks are 0-5 ATS in their last five road games.
Seattle is 8-2 in its last 10 games against San Francisco, going 6-4 ATS in those games.
The total has gone Under in each of the Seahawks’ last seven games

Seahawks at 49ers: Key injuries

Seahawks

RB DeeJay Dallas (ankle) out
CB Jayson Stanley (hamstring) out
G Mike Iupati (neck) questionable
TE Greg Olsen (foot) questionable
RB Carlos Hyde (illness) questionable
S Damarious Randall (foot) questionable
OT Brandon Shell (ankle) questionable

49ers

DL Kevin Givens (non-injury) out
DT Javon Kinlaw (knee) out
DB Tarvarious Moore (ankle) questionable
CB Emmanuel Moseley (hamstring) questionable
LB Mark Nzeocha (illness) questionable
WR Deebo Samuel (hamstring) out
CB Richard Sherman (calf) out
CB K’Waun Williams (shin) out
WR Brandon Aiyuk (ankle) out
LB Dre Greenlaw (calf) out

Seahawks at 49ers: Odds, betting lines, predictions and picks

Prediction

Seahawks 27, 49ers 20

Money line (?)

The 49ers have nothing to play for and could opt to take a guarded approach with some of their banged-up players. They’ve also shown very few signs of life in the last two months, only the Los Angeles Rams and Arizona Cardinals since November began.

The Seahawks have stepped up on defense and should be able to slow down San Francisco’s offense, rolling to a win by at least one score. Take the SEAHAWKS (-295).

Against the spread (?)

I like the Seahawks against the spread even more than the money line. They’ve had trouble covering lately, but the 49ers are a beatable team and Seattle’s defense has improved significantly since the last meeting between these teams.

Take the SEAHAWKS -6.5 (-110) to cover and head into the postseason riding some momentum.

Over/Under (?)

This one’s tricky. I don’t expect the 49ers to move the ball that consistently against the Seahawks, but Seattle is also going up against a strong 49ers defense. The Seahawks will find the end zone a few times and the 49ers will break a long play or two to spark the offense.

Take the OVER 45.5 (-115) in this game, even though the total has gone Under in each of the Seahawks’ last seven.

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Also see:

Seahawks ‘going for it,’ likely won’t rest starters (Seahawks Wire)
Jimmy Garoppolo unlikely to play vs. Seattle (Niners Wire)

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