San Francisco Giants vs. Cleveland Guardians odds picks prediction spread over/under betting line

The San Francisco Giants (5-2) face the Cleveland Guardians (4-3) in the second game of a three-game interleague set Saturday at Progressive Field in Cleveland. First pitch is scheduled for 6:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Guardians odds with MLB picks and predictions.

Season series: Giants lead 1-0

The Giants spoiled the Guardians’ home opener with a 4-1 victory Friday. Former White Sox LHP Carlos Rodon helped keep the Cleveland bats cool for his new squad, as he limited the home side to just 3 hits.

The Guardians had rolled up 44 total runs in the previous four games before the offense ground to a halt against the southpaw Rodon. The Under result was the first for Cleveland since their second game of the regular season at Kansas City April 9.

Giants at Guardians: Projected starters

RHP Anthony DeSclafani vs. RHP Cal Quantrill

DeSclafani (0-0, 4.91 ERA) makes his second start. He allowed 2 ER on 8 H and 1 BB with 5 K across 3 2/3 IP in his first start versus the Miami Marlins Sunday.

Posted a 5-4 record, 3.22 ERA and .225 opponent batting average across 95 IP in 17 road starts last season.
Allowed 2 runs on 7 hits and 2 walks with 6 strikeouts across 6 innings in a no-decision as a member of the Cincinnati Reds when he last faced Cleveland July 6, 2019.

Quantrill (1-0, 3.60 ERA) allowed 2 ER on 4 H and 1 BB with 2 K in 5 IP at the Kansas City Royals Sunday in his season debut.

The Guardians supported Quantrill with 17 runs of offense in his first outing of the season at Kauffman Stadium Sunday.
Was outstanding at Progressive Field in 2021, posting a 6-0 record, 2.35 GAA and .224 OBA with 76 strikeouts across 92 IP in 14 starts and eight relief appearances.

Giants at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:55 a.m. ET.

Money line (ML): Giants -108 (bet $108 to win $100) | Guardians -112 (bet $112 to win $100)
Run line (RL)/Against the spread (ATS): Giants -1.5 (+145) | Guardians +1.5 (-180)
Over/Under (O/U): 8.5 (O: +100 | U: -125)

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Giants at Guardians picks and predictions

Prediction

Giants 5, Guardians 3

Money line

The GIANTS (-108) have been interleague beasts, winning five of the past six against the American League, and they have handled the Cleveland franchise with nine victories in the past 10 tries.

While Quantrill failed to lose a decision in 2021 at home, he will struggle against a Giants team that won 107 games last season.

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Run line/Against the spread

GIANTS -1.5 (+145) are worth playing lightly, as they covered the run line in Friday’s interleague series opener. While three of their five victories so far have been 1-run wins, their pitching has been excellent lately. The Giants have yielded just 4 total runs in the past three games while piling up 19 runs scored. Look for more of the same Saturday.

Over/Under

The lean is to the UNDER 8.5 (-125), mostly due to San Francisco’s pitching. The Giants have cashed the Under in five of their last six games, allowing 2 or fewer runs in five of their previous six outings.

The Guardians had four straight Over results before Friday’s low-scoring loss. The offense has overshadowed the pitching, which has turned in a 2.90 ERA, ranking sixth in the majors during the early going.

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The San Francisco Giants (4-2) start a 3-game interleague series with the Cleveland Guardians (4-2) Friday at Progressive Field. First pitch is scheduled for 7:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Guardians odds with MLB picks and predictions.

The Guardians and Giants have not played each other since 2017. The Giants lead 5-14 in the regular season and have won 10 of the last 12 meetings between the teams.

San Francisco won back-to-back games over the San Diego Padres to win their 3-game series 2-1. The Giants outscored the Padres 17-7.

Cleveland has won 4 consecutive games after dropping its first two of the season, which includes a split in their 4-game set with the Royals and a sweep in the 2-game interleague miniseries with the Reds earlier this week.

Giants at Guardians: Projected starters

San Francisco RHP Carlos Rodon vs. Cleveland LHP Zach Plesac

Rodon (0-0, 1.80 ERA) picked up a no-decision in San Francisco’s 2-1 home loss to the Marlins Saturday. He went for 5 IP, allowing just 1 ER on 3 H and 2 BB with 12 K.

2021 vs. Guardians: 2-0 with a 2.70 ERA (20 IP, 6 ER), 0.90 WHIP and 10.4 K/9 in 3 starts for the Chicago White Sox.
vs. Guardians on the current roster: 3.05 FIP with a .176 batting average, .257 wOBA, .309 expected slugging percentage, 24.1 K% and 90.0 mph exit velocity in 83 plate appearances.

Plesac (0-0, 0.00 ERA), also earned a no-decision in Cleveland’s 1-0 loss in K.C. Saturday. He gave up 0 ER on 3 H, 0 BB and 5 K in 5 2/3 IP.

April splits: 1-3 with a 4.78 ERA (32 IP, 17 ER), 1.06 WHIP and 5.9 K/9 in 6 starts.

Giants at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:12 a.m. ET.

Money line (ML): Giants -155 (bet $155 to win $100) | Guardians +125 (bet $100 to win $125)
Run line (RL)/Against the spread (ATS): Giants -1.5 (+110) | Guardians +1.5 (-135)
Over/Under (O/U): 7.5 (O: -125 | U: +100)

Giants at Guardians picks and predictions

Prediction

Guardians 4, Giants 2

Money line

SPRINKLE on the GUARDIANS (+125), if at all, because I see more value in Cleveland’s RL, which is going for a relatively cheap price.

The Guardians have the hottest bats in baseball through the first week, Friday is their home opener and Progressive Field is a hitter-friendly ballpark. Also, Cleveland’s lineup is familiar with Rodon who was a divisional foe and played for the Chicago White Sox from 2015-21.

This Giants (-155) lineup has yet to face Plesac, who I expect to be one of the best middle-of-the-rotation starters in MLB. Cleveland’s organization is a pitching factory and the rotation alone can put the Guardians in playoff contention.

However, San Francisco is somehow underrated coming into this year despite winning the NL West last season and I prefer Cleveland’s RL.

Run line/Against the spread

Definitely BET the GUARDIANS +1.5 (-135) instead of or heavier than their ML because Cleveland should beat the Giants -1.5 (+110) outright. but the RL is just too cheap to pass up.

Furthermore, there’s reverse line movement in Cleveland’s direction as nearly two-thirds of the money is on San Francisco but the line has moved slightly towards the Guardians. This suspicious line movement tells us the oddsmakers are trying to entice more pro-Giants action.

A Cleveland ML bet should cash but my preferred play is the GUARDIANS +1.5 (-135).

Over/Under

LEAN to the UNDER 7.5 (+100)

This is a sharp total and there are two quality starters on the mound. Plesac is due for a breakout season and Rodon was an AL Cy Young contender last season and his pitching peripherals versus this Cleveland lineup are solid.

But Cleveland’s lineup is hot and powered by Guardians 3B Jose Rameriz, who was recently given a hefty contract extension and is dialed in at the plate.

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If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

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