San Francisco 49ers at Tennessee Titans odds, picks and predictions

Analyzing Saturday’s San Francisco 49ers at Tennessee Titans odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers visit the Tennessee Titans as both teams open the preseason. Kickoff from Nissan Stadium is set for 7 p.m. ET (NFL+). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Titans odds, and make our expert NFL picks and predictions.

San Francisco finished atop the NFC West last year with a 12-5 record en route to a Super Bowl appearance, where the Niners lost 25-22 in OT to the Kansas City Chiefs. The 49ers are in a standoff with WR Brandon Aiyuk, the team’s leading receiver last year, who is demanding a trade.

Tennessee ended last year with a 6-11 record, finishing in last place in the AFC South. The Titans drafted OT JC Latham with the 7th overall pick in the draft. The Titans lost RB Derrick Henry to the Baltimore Ravens in free agency.

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49ers at Titans odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:33 p.m. ET.

  • Moneyline (ML) 49ers +200 (bet $100 to win $200) | Titans -250 (bet $250 to win $100)
  • Against the spread (ATS): 49ers +5.5 (-110) | Titans -5.5 (-110)
  • Over/Under (O/U): 38.5 (O: -110 | U: -110)

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49ers at Titans picks and predictions

Prediction

Titans 21, 49ers 10

Moneyline

PASS.

I like the Titans to pick up the win and cover as -250 favorites, but this heavy of a favorite is never worth the risk of betting on. Bet on the spread and/or total instead.

Against the spread

LEAN TITANS -5.5 (-110).

The Titans have expressed that most starters will play in a few drives in this game, which should give Tennessee enough of an edge to cover here when the backups take the reins.

This is a lean because neither team has great backups and because there are always unknowns in the preseason, especially with a team like Tennessee that has so many young guys.

Over/Under

BET UNDER 38.5 (-110).

Both squads are known for having very stout defensive units, and with both teams having backup QBs who have never done much in the NFL, the defenses should shine here.

With coach Mike Vrabelout the door for Tennessee, this defense may be slightly worse, but the pieces are still in place for me to have faith in this unit for this outing.

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San Francisco 49ers at Tennessee Titans odds, picks and predictions: Player prop bets

Analyzing the San Francisco 49ers at Tennessee Titans Week 16 matchup and offering up expert picks and predictions on the top player prop bets.

The San Francisco 49ers (8-6) will try to keep things rolling on Thursday night when they visit Nissan Stadium to take on the Tennessee Titans (9-5) as both teams push for a playoff berth in their respective conferences. Kickoff will be at 8:20 p.m. ET. Below, we look at the 49ers vs. Titans prop bet odds and lines, and make our best NFL picks, predictions and bets.

The 49ers have won two straight games and five of their last six, showing that they’re one of the better teams in the NFC right now. Four of those wins were by at least eight points and three of them were by 18 or more. They’ve scored at least 26 points in five of those six games, too, so the offense has found a groove in the last month and a half.

The Titans don’t look like the same team that we saw before RB Derrick Henry went down with an injury, being forced to rely heavily on QB Ryan Tannehill and the passing attack. They’re coming off a 19-13 loss to the Steelers in Week 15 and their only win in the last four games came against the Jaguars.

49ers at Titans prop bet picks and predictions

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 10 a.m. ET.

49ers WR Deebo Samuel OVER 3.5 receptions (-152)

Samuel has become more of an offensive weapon than a wide receiver this season, only catching seven passes in his last four games and carrying it 28 times in that same span.

However, he has at least four receptions in nine games this season, and he’s coming off a game with four catches on five targets. He’ll keep his great season rolling tonight.

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Titans RB D’Onta Foreman UNDER 48.5 rushing yards (-118)

Foreman hasn’t played more than 50% of the offensive snaps all season and even though he carried it 22 times on just 31 snaps last week, this is a game where the Titans might have to throw the ball more if the 49ers grab an early lead. With RB Dontrell Hilliard eating into Foreman’s touches, I think he fails to top 49 yards against a good 49ers defense.

Titans QB Ryan Tannehill OVER 20.5 completions (+100)

Tannehill has completed at least 20 passes in three of his last four games and has hit 21-plus completions seven times. He’s a near-lock for at least 18 completions per game, and with the script potentially causing the Titans to throw the ball more, this could be a game where he throws it 35-plus times.

49ers QB Jimmy Garoppolo OVER 1.5 TD passes (-118)

Garoppolo has quietly played very well in the last two months, throwing 12 touchdown passes and four interceptions in his last seven games. He’s thrown two touchdown passes in five of those games, completing a high number of his passes and allowing his receivers to gain yards after the catch. He’s a good bet to throw multiple touchdown passes tonight.

49ers WR Deebo Samuel anytime TD scorer (+100)

Since Samuel became more of a running back in Week 10, he’s scored six rushing touchdowns and also added one touchdown reception. Getting him at even money to score a touchdown at some point tonight is a great value because Kyle Shanahan loves using him around the goal line as a runner. And he’s always a threat to turn a short pass into a big gain (or touchdown), too.

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