NFC Championship Game: San Francisco 49ers at Philadelphia Eagles odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Philadelphia Eagles odds and lines, with expert NFL picks, predictions and best bets.

[mm-video type=video id=01gqss5fpqb1w1q2hhjc playlist_id=none player_id=01evcg1x9ny8tb834m image=https://images2.minutemediacdn.com/image/upload/video/thumbnail/mmplus/01gqss5fpqb1w1q2hhjc/01gqss5fpqb1w1q2hhjc-d3a793d413793468f3adb10aae264917.jpg]

The San Francisco 49ers (15-4) battle the Philadelphia Eagles (15-3) Sunday in the NFC Championship Game. Kickoff from Lincoln Financial Field is scheduled for 3 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Eagles odds, and make our expert NFL picks and predictions.

San Francisco edged past the Dallas Cowboys 19-12 in the Divisional Round, covering as 3.5-point home favorites. The 49ers have won 12 consecutive games, have covered the spread in 3 straight games and are 9-1 against the spread (ATS) in the last 10. They’ve been a moneymaker this season, going 13-6 ATS combined in the regular season and playoffs.

QB Brock Purdy, aka Mr. Irrelevant in last year’s draft, is 7-0 since taking over the starting role after Jimmy Garoppolo suffered a broken foot in Week 13. The 49ers offense has been great, averaging 365.6 yards per game during the regular season to rank 5th in the league — it averaged 408.5 YPG in 2 playoff games — but the defense has performed even better. The 49ers defense ranks 1st in total yards allowed (300.6 YPG), 2nd against the rush (77.7) and 1st in opponent’s points scored (16.3 PPG).

The Eagles demolished the division rival New York Giants 38-7 last week in their 1st playoff game coming off a 1st-round bye. They easily covered as 8-point home favorites. Philadelphia is only 1-4 ATS in its last 5 games and 9-9 ATS overall, but it is 7-3 ATS in its last 10 home games.

MVP candidate QB Jalen Hurts has led the Eagles to a top-ranked offense this season. They rank top-10 in the league in total yards per game (3rd; 389.1), pass yards per game (9th; 241.5), rush yards per game (5th; 147.6) and points scored per game (3rd; 28.1).

This will be the first time San Francisco and Philadelphia have faced each other since 2021, a game in which the 49ers beat the Eagles 17-11 to cover as 3-point road favorites.

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

49ers at Eagles odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10 p.m. ET.

  • Moneyline (ML): 49ers +130 (bet $100 to win $130) | Eagles -150 (bet $150 to win $100)
  • Against the spread: 49ers +2.5 (-101) | Eagles -2.5 (-119)
  • Over/Under (O/U): 45.5 (O: -112 | U: -108)

Catch the excitement and bet with Tipico

Double Down, Ohio! Deposit $200, Get $250. Bet now!

In Colorado and New Jersey, claim your 100% Deposit Match up to $250 now. Bet now! 21+, see Tipico.com for Terms and Conditions.

49ers at Eagles key injuries

49ers

  • QB Jimmy Garoppolo (foot) out
  • RB Elijah Mitchell (groin) questionable

Eagles

  • None

Play our free daily Pick’em Challenge and win! Play now!

49ers at Eagles picks and predictions

Prediction

Eagles 24, 49ers 20

Moneyline

PASS.

With the Eagles’ odds set at -150, the better play is laying the points with the -119 juice.

Against the spread

LEAN EAGLES -2.5 (-119).

Philadelphia has played great in front of their home crowd this season where they boast an 8-2 record.

The Eagles defense ranks 2nd in the league in total yards allowed per game (301.5), 1st in passing yards per game (179.8) and 3rd in takeaways (27). The defense will prove to be too much for Purdy, who will be flying across the country and playing in Northeastern weather conditions for the first time in his young career.

Although San Francisco has plenty of offensive weaponry in their backfield, expect Coach of the Year candidate Nick Sirianni and defensive coordinator Jonathan Gannon to draw up some defensive schemes to confuse the young Niners QB.

In the last 10 meetings between these teams, the favorite is 7-3 ATS.

Over/Under

BET UNDER 45.5 (-108).

With 2 top-ranked defenses, points will be hard to come by. San Francisco ranks No. 1 in the NFL in total yards allowed per game (300.6) and the Eagles rank No. 2 (301.5). San Francisco ranks No. 2 in takeaways (28) and the Eagles rank No. 3 (27). With a chance to go to the Super Bowl on the line, both defenses will surely be on their A-game.

The Under is 7-0 in the 49ers’ last 7 playoff games and 4-1 in the Eagles’ last 5 games overall. The Under is also 4-0 in the last 4 meetings between these 2 teams.

More NFL Championship Games coverage

Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in OH, CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow @seth_orlemann on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWireTitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]