San Francisco 49ers vs. Los Angeles Rams odds predictions pick betting line spread

San Francisco 49ers at LA Rams odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at LA Rams odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (1-1) are visiting the LA Rams (0-2) on Sunday afternoon in a rivalry game between NFC West foes. Kickoff from SoFi Stadium in Inglewood, Calif., is set for 4:25 p.m. ET (FOX).

Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Rams odds, and make our expert NFL picks and predictions.

The 49ers are coming off a shocking 23-17 loss to the Minnesota Vikings in Week 2, a game in which they were 4-point road favorites. RB Christian McCaffrey remains out with Achilles tendinitis, and WR Deebo Samuel will also miss this game with a calf injury.

The Rams are 0-2 for the 1st time under coach Sean McVay, with their most recent loss being a 41-10 defeat at the hands of the Arizona Cardinals. They’re arguably the most injured team in the NFL right now, missing WRs Cooper Kupp and Puka Nacua, starting linemen Jonah Jackson and Steve Avila, as well as S John Johnson III, among others.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Friday at 6:54 p.m. ET.

Moneyline (ML): 49ers -300 (bet $300 to win $100) | Rams +240 (bet $100 to win $240)
Against the spread (ATS): 49ers -6.5 (-115) | Rams +6.5 (-105)
Over/Under (O/U): 43.5 (O: -105 | U: -115)

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49ers at Rams key injuries

49ers

DE Nick Bosa (rib) probable
S Talanoa Hufanga (knee) probable
TE George Kittle (hamstring) questionable
RB Christian McCaffrey (Achilles) out
WR Deebo Samuel (calf) out
CB Charvarius Ward (hamstring/knee) questionable
LB Dee Winters (ankle) probable

Rams

OL Steve Avila (knee) out
OL Kevin Dotson (foot) probable
CB Cobie Durant (toe) probable
OL Jonah Jackson (shoulder) out
S John Johnson III (shoulder) out
WR Cooper Kupp (ankle) out
WR Puka Nacua (knee) out
CB Darious Williams (hamstring) out

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49ers at Rams picks and predictions

Prediction

49ers 27, Rams 17

Moneyline

The 49ers are heavily favored in this game, though the ML has come down slightly to -300 after it opened at -375 on Monday. Either way, it’s not worth taking the 49ers to win outright at that number. Even with San Francisco winning 9 of the last 10 regular-season meetings against the Rams, that line is far too juiced to bet.

PASS on the ML.

Against the spread

The Rams looked completely overmatched against the Cardinals, and on paper, the 49ers are a way better team than Arizona. Injuries could be a slight concern for San Francisco in this game, but not as worrisome as the Rams’ decimated roster.

The Rams can’t stop the run and for San Francisco, that’s what’s been working best on offense with RB Jordan Mason posting back-to-back 100-yard games to open the year. The 49ers should be able to control time of possession and limit the opportunities for Los Angeles’ offense in this one.

BET 49ERS -6.5 (-115).

Over/Under

The total has dropped from 44.5 to 43.5, which is a key number. With the 49ers’ ability to run the ball and the Rams’ banged-up offense that’s missing Kupp and Nacua, this could be a lower-scoring game than we’re used to seeing from these rivals.

PASS on the total at 43.5, but if it moves back to 44.5, LEAN UNDER. The Rams could struggle to move the ball and San Francisco could shorten the game with its rushing attack.

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San Francisco 49ers at Los Angeles Rams odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Los Angeles Rams odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (1-0) and Los Angeles Rams (1-0) renew their rivalry Sunday in the first of two meetings this season. Kickoff from SoFi Stadium is set for 4:05 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Rams odds, and make our expert NFL picks and predictions.

The 49ers looked like one of the teams to beat this year in Week 1 as they crushed the Pittsburgh Steelers 30-7 as 1-point favorites. San Francisco was carried on offense by RB Christian McCaffrey who put up 152 rushing yards and 1 TD on 22 carries while the defense swarmed Steelers QB Kenny Pickett, holding Pittsburgh to just 15 first downs — 3 of which came from penalties.

The Rams stunned a lot of people with a lopsided win of their own in Week 1, beating the Seattle Seahawks 30-13 as 4-point underdogs. Los Angeles held Seattle to just 12 total yards in the 2nd half while outscoring them 23-0 over the final 30 minutes. QB Matthew Stafford led the way with 334 yards passing, although he didn’t throw a touchdown pass in the victory.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:46 a.m. ET.

Moneyline (ML): 49ers -350 (bet $350 to win $100) | Rams +280 (bet $100 to win $280)
Against the spread (ATS): 49ers -7.5 (-110) | Rams +7.5 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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49ers at Rams key injuries

49ers

LB Dre Greenlaw (groin) questionable
CB Samuel Womack (knee) questionable

Rams

WR Puka Nacua (oblique) questionable

49ers at Rams picks and predictions

Prediction

49ers 27, Rams 21

Moneyline

This game got a lot more interesting after the Rams blew out the Seahawks in the opener. They came into the season looking like they would struggle mightily without the stars they dumped this offseason, but played much better than expected.

That being said, the 49ers (-350) should still win this game, as they have their last 8 regular-season matchups with the Rams. They have L.A.’s number and I expect that to continue, I’m just not betting the moneyline at -350 in a rivalry game.

PASS.

Against the spread

Everything points to the 49ers covering the spread in this one. They’re the better team, they’re healthier and they’re 8-2 ATS in their last 10 games against the Rams. Yet, I find myself thinking the Rams will cover.

The offensive line is improved, the defense played better than expected and Nacua looks like the real deal as a 5th-round rookie (although his status for Sunday is unknown).

BET RAMS +7.5 (-110) to cover, but pass if this number gets down to 7.

Over/Under

The total went Under in the first game for both the Rams and 49ers this season and has cashed in 2 of the last 4 meetings between these teams.

However, the Rams’ defense isn’t as good as it seemed last week and the offense is still very capable of putting up points with Stafford, Nacua and a much-improved offensive line.

BET OVER 44.5 (-110).

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San Francisco 49ers at Los Angeles Rams odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Los Angeles Rams odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (3-4) and Los Angeles Rams (3-3) will square off in their 2nd meeting of the season Sunday afternoon. Kickoff between these two NFC West foes will be at 4:25 p.m. ET (FOX) from SoFi Stadium in Inglewood. Below, we analyze Tipico Sportsbook‘s lines around the 49ers vs. Rams odds, and make our expert NFL picks and predictions.

The 49ers have been blown out in each of their last 2 games, dropping below .500. The Falcons beat them, 28-14, in Week 6 and the Chiefs dismantled their defense en route to a 44-23 victory last week. Now with RB Christian McCaffrey in the fold, the 49ers have one of the better skill groups in the NFL, and this will be the 2nd time in 3 weeks that McCaffrey faces the Rams defense; he did so in Week 6 with the Panthers. However, they must suit up without WR Deebo Samuel (hamstring) Sunday.

The Rams beat the Panthers in their last game before the Week 7 bye, improving their record to 3-3 after losing 2 straight games. They’re a half-game behind the Seahawks for the lead in the division, but it hasn’t been thanks to the offense, which ranks 29th in points per game this season. They’ll try to snap their 7-game regular-season losing streak to the 49ers this weekend.

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49ers at Rams odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10 a.m. ET.

Moneyline (ML): 49ers -115 (bet $115 to win $100) | Rams -103 (bet $103 to win $100)
Against the spread (ATS): 49ers -0.5 (-115) | Rams +0.5 (-105)
Over/Under (O/U): 42.5 (O: -108 | U: -112)

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49ers at Rams key injuries

49ers

DL Arik Armstead (foot, ankle) questionable
DL Samson Ebukam (Achilles’) questionable
LB Dre Greenlaw (calf) questionable
FB Kyle Juszczyk (finger) DNP
WR Deebo Samuel (hamstring) out
DB Jimmie Ward (hand) probable

Rams

RB Cam Akers (personal) out
WR Brandon Powell (ankle) questionable

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49ers at Rams picks and predictions

Prediction

49ers 21, Rams 18

Moneyline

The 49ers have the Rams’ number, playing a more physical style of football every time these teams meet. It has resulted in a 7-game winning streak over the Rams in the regular season, and it’s no fluke.

I like the 49ERS (-115) to win again on Sunday, despite being on the road without Samuel. Their fans travel well each time they face the Rams at SoFi Stadium, so Los Angeles’ home-field advantage won’t be as strong as usual.

The 49ers’ defensive front is just too good compared to the Rams’ shorthanded offensive line.

Against the spread

The 49ers are a perfect 6-0 ATS in their last 6 games against the Rams, so taking them to cover the spread isn’t a bad idea. But if you’re already betting the money line at -115, taking the 0.5-point spread at -115 isn’t very worthwhile.

PASS here.

Over/Under

The total has gone Under in 5 of the last 6 meetings between the Rams and 49ers dating back to 2020. Neither offense looked great the last time out, with the 49ers putting up just 23 points on the Chiefs, and the Rams scoring just 24 on the Panthers.

The Rams offense, in particular, has been a mess this season and was limited to 9 points in Week 4 against San Francisco. Bet the UNDER 42.5 (-112).

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San Francisco 49ers at Los Angeles Rams odds, picks and prediction

Analyzing Sunday’s San Francisco 49ers at Los Angeles Rams NFC Championship odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (12-7) and Los Angeles Rams (14-5) square off in the NFC Championship Sunday with a trip to Super Bowl LVI on the line. Kickoff from SoFi Stadium is at 6:30 p.m. ET (on FOX). Below, we look at the 49ers vs. Rams odds and lines, and make our best NFL picks, predictions and bets.

San Francisco upset the Dallas Cowboys and Green Bay Packers in the first two rounds of the playoffs. The 49ers have won four in a row, the last three as underdogs. Their most recent win came against the Packers in the Divisional Round, a 13-10 victory despite not scoring an offensive touchdown. Their only touchdown came on SS Talanoa Hufanga’s 6-yard return of a blocked punt with 4:41 to go to tie it at 10-10, and K Robbie Gould’s field goal won it as time expired.

The Rams were stunned by the 49ers in Week 18 after blowing a 17-point lead, losing 27-24 in overtime. Since then, Los Angeles crushed the visiting Arizona Cardinals in a Wild Card matchup and staved off the Tampa Bay Buccaneers in the Divisional Round, winning on K Matt Gay’s field goal as time expired. This postseason, QB Matthew Stafford has 6 touchdowns (4 passing, 2 rushing) against zero interceptions in notching the first two playoff victories of his career.

49ers at Rams odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:27 a.m. ET.

Money line: 49ers +145 (bet $100 to win $145) | Rams -180 (bet $180 to win $100)
Against the spread (ATS): 49ers +3.5 (-115) | Rams -3.5 (-105)
Over/Under (O/U): 45.5 (O: -112 | U: -108)

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49ers at Rams key injuries

49ers

OL Trent Williams (ankle) questionable

Rams

WR Van Jefferson (knee) questionable
OL Joe Noteboom (chest) doubtful
S Taylor Rapp (concussion) questionable

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49ers at Rams odds, lines, predictions and picks

Prediction

Rams 27, 49ers 20

Money line

BET LOS ANGELES (-180) to win outright.

The Rams should have steamrolled the 49ers in Week 18. Los Angeles led 17-0 in the second quarter until the San Francisco kicked a field goal as the first-half clock expired. The Rams blew the lead in the second half after a couple of miscommunications in the secondary led to big plays.

L.A.s should have blown out Tampa Bay in the Division Round, too, but 4 lost fumbles and a missed field goal let the Bucs back in it.

I wouldn’t be surprised if the Rams beat the 49ers by double digits in this game. It’s a matter of not beating themselves with turnovers and missed tackles because on paper, Los Angeles is the better team.

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Against the spread

BACK LOS ANGELES -3.5 (-105). The Rams easily covered the spread in their last two playoff games and are 10-9 ATS this season.

The 49ers are an impressive 11-8 after covering in their last four and in nine of their last 11 games, but this line should be a bit higher than 3.5 points.

More often than not, when the Rams win, they win comfortably. Only two of their 12 regular-season win were by fewer than 7 points.

Over/Under

TAKE THE OVER 45.5 (-112).

In the last 10 meetings between these NFC West rivals, the total has only gone Over 3 times.

But this line is quite low at just 45.5 points. That’s because the 49ers have only scored 2 offensive touchdowns this postseason and are coming off a game in which they only scored 13 points.

If the Rams can give Stafford time, the offense will move the ball consistently. With how poorly L.A. tackled in the regular-season finale loss to San Francisco (19 missed tackles), the 49ers should gain yardage consistently on the ground, too.

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San Francisco 49ers at Los Angeles Rams odds, picks and prediction

Analyzing Sunday’s San Francisco 49ers at Los Angeles Rams odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (9-7) can ensure their spot in the postseason with a win Sunday when they visit the Los Angeles Rams (12-4) at SoFi Stadium. Kickoff in this NFC West matchup will be at 4:25 p.m. ET. Below, we look at the 49ers vs. Rams odds and lines, and make our best NFL picks, predictions and bets.

The 49ers have gone 7-3 in their last 10 games after starting the season 2-4, completely turning things around to get into position to make the playoffs. Their most recent win was a 23-7 victory over the Houston Texans in Week 17, a game that rookie QB Trey Lance started in place of the injured QB Jimmy Garoppolo.

San Francisco has played well in recent weeks, scoring at least 23 points in seven of its last eight games, and is taking on a team they’ve beaten five times in a row.

The Rams have since won five games in a row since dropping three consecutive games in November, beating the likes of the Arizona Cardinals, Minnesota Vikings and Baltimore Ravens in that stretch. The Rams still haven’t clinched the NFC West, however, with Arizona sitting just one game back in the standings, but will be crowned the division champion with a win Sunday.

49ers at Rams odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:02 a.m. ET.

Money line: 49ers +155 (bet $100 to win $155) | Rams -190 (bet $190 to win $100)
Against the spread (ATS): 49ers +3.5 (-112) | Rams -3.5 (-108)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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49ers at Rams key injuries

49ers

LT Trent Williams (elbow) questionable
QB Jimmy Garoppolo (thumb) questionable
CB K’Waun Williams (COVID-19) questionable
LB Azeez Al-Shaair (knee) questionable
LB Dre Greenlaw (groin) questionable
S Jaquiski Tartt (shoulder) questionable

Rams

None

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49ers at Rams odds, lines, predictions and picks

Prediction

Rams 27, 49ers 21

Money line

The 49ers have owned the Rams in the last three years. They’ve won five straight against Los Angeles since 2019, including a 31-10 victory in Week 10 of this season. However, the Rams are rolling right now and have managed to win five straight despite QB Matthew Stafford‘s turnover issues.

I like the RAMS (-190) to win outright at home with the division title on the line.

Against the spread

The 49ers are 7-3 ATS against the Rams in their last 10 meetings. They’ve owned this rivalry since Sean McVay took over as the Rams’ head coach. However, the 49ers have major injury concerns, while Los Angeles is as healthy as it’s been all year.

Take the RAMS -3.5 (-108) at almost even money to cover the spread.

Over/Under

The Over/Under is split 5-5 in the last 10 games between these teams. The Under is also 6-4 in the last 10 games for both the Rams and 49ers this season.

With San Francisco’s secondary potentially missing key pieces and the Rams offense moving the ball well — aside from Stafford’s turnovers — I see this game going OVER 44.5 (-110).

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