The San Francisco 49ers (4-5) face the Jacksonville Jaguars (2-7) on the road Sunday in Week 11. Kickoff is 1 p.m. ET at TIAA Bank Stadium. Below, we look at the 49ers vs. Jaguars odds and lines, and make our best NFL picks, predictions and bets.
The 49ers picked up their first win at Levis Stadium in over a year when they defeated the Los Angeles Rams 31-10 Monday. QB Jimmy Garoppolo threw both his touchdown passes to WR Deebo Samuel who finished with 133 total yards, while S Jimmie Ward returned from injury to intercept two passes, returning one for a touchdown.
The Jaguars lost 23-17 to the Indianapolis Colts in Week 10. QB Trevor Lawrence completed only 16 of 35 passes for 162 yards. The Jaguars have averaged only 11 points per game in their last three contests and Lawrence has not thrown a touchdown pass in consecutive games.
Also see: All Week 11 odds and lines
49ers at Jaguars odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 10 a.m. ET.
- Money line: 49ers -290 (bet $290 to win $100) | Jaguars +225 (bet $100 to win $225)
- Against the spread (ATS): 49ers -6.5 (-110) | Jaguars +6.5 (-110)
- Over/Under (O/U): 45.5 (O: -105 | U: -115)
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49ers at Jaguars key injuries
49ers
- RB Elijah Mitchell (rib, finger) doubtful
- DT Maurice Hurst (calf) out
- RB JaMycal Hasty (ankle) out
Jaguars
- RB James Robinson (heel, knee) questionable
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49ers at Jaguars odds, lines, predictions and picks
Prediction
49ers 20, Jaguars 16
Money line
The 49ers have been wildly inconsistent. They’ve scored over 30 points in three of their four wins and scored under 20 points in three of their five losses. San Francisco is 3-1 on the road.
The Jaguars have won both of their last “home” games, although one of them was in London, England. However, they continue to struggle on offense and have not scored more than 21 points in any game.
The line is almost not worth a bet on the 49ers, but betting the Jaguars is risky business. San Francisco looked like a team ready to make some noise in the NFC wild-card race last week.
Take the 49ERS (-290).
Against the spread
The 49ers are 3-6 ATS this season but had covered the spread in three of their four wins. They are 2-5 ATS as favorites.
The Jaguars covered the spread in three of their last four games despite their offensive struggles.
Take the JAGUARS +6.5 (-110).
Over/Under
Only two of the Jaguars’ nine games this season have hit the Over, and they’re the only two games that would have gone Over this week’s projected total.
The 49ers have seen three of their last four games go Over the projected total. Two of their four wins went Over the projected total.
Jacksonville’s defense is playing better as of late and their offense still struggles, so take UNDER 45.5 (-115).
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