Arizona Cardinals home favorites over San Francisco 49ers in Week 16

The San Francisco 49ers are underdogs in their Week 16 home matchup with the rival Arizona Cardinals.

The Arizona Cardinals (8-6) play their home finale in Week 16 against the San Francisco 49ers (5-9). The two teams will play in one of three Saturday games, kicking off at 4:30 p.m. at State Farm Stadium in Glendale, AZ. Below, we take a look at the early betting odds and lines at BetMGM Sportsbook.

The Cardinals are coming off their second straight win. QB Kyler Murray passed for a career-high 406 yards and had three touchdown passes and a rushing touchdown in a 33-26 victory over the Philadelphia Eagles.

The 49ers lost their third straight game on Sunday, and sixth in their last seven games, falling 41-33 to the Dallas Cowboys. 49ers QB Nick Mullens had two interceptions and lost a fumble, and the team turned the ball over four times in the loss.

49ers at Cardinals betting odds, spread and line

Odds via BetMGM; last updated Monday at 7:55 p.m. ET. 

  • Money line: 49ers +160 (bet $100 to win $160) / Cardinals -190 (bet $190 to win $100) | Bet now
  • Against the spread: 49ers +4, -110 (bet $110 to win $100) / Cardinals -4, -110 (bet $110 to win $100) | Bet now
  • Total: 48.5, Over -110 (bet $110 to win $100) / Under -110 (bet $110 to win $100) | Bet now

New to NFL betting?

The 49ers, at +160 odds, have an implied 38.46% chance of winning, or 8/5 fractional odds. If San Francisco wins outright or loses by fewer than 4 points, a 49ers +4 (-110) bet wins.

Place your legal, online NFL bets in CO, IN, NJ, PA, TN and WV at BetMGM. Risk-free first bet! Terms and conditions apply. Bet now!

At -190 odds, the Cardinals have an implied 65.52% chance of beating the 49ers or 10/19 fractional odds. Arizona must win by 5 or more points for a Cardinals -4 (-110) ATS ticket to cash. A 4-point Arizona win would result in a push.

Also see:

Get some action on this NFL game or others by signing up and betting at BetMGM. If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com. Please gamble responsibly.

Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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Dallas Cowboys home underdogs vs. San Francisco 49ers in Week 15

The San Francisco 49ers are betting favorites in their Week 15 road matchup with the Dallas Cowboys.

The San Francisco 49ers (5-8) are on the road and take on the Dallas Cowboys (4-9) in a battle of two last-place teams in Week 15. Kickoff is at 1 p.m. ET at AT&T Stadium in Arlington, Texas. Below, we take a look at the early 49ers-Cowboys Week 15 betting odds and lines at BetMGM Sportsbook.

San Francisco is coming off its second straight loss and fifth in six games. The 49ers were fantastic defensively in a 23-15 Week 14 loss to the Washington Football Team, allowing only 193 total yards of offense and taking the ball away three times; however, the offense turned it over three times as well and had an interception and a fumble each returned for touchdowns. The 49ers were eliminated from NFC West contention.

The Cowboys beat the Cincinnati Bengals 30-7 Sunday. QB Andy Dalton threw 2 touchdown passes against his former team and the defense forced three turnovers, returning a fumble for a touchdown.

49ers at Cowboys betting odds, spread and line

Odds via BetMGM; last updated Monday at 1:25 p.m. ET. 

  • Money line: 49ers -125 (bet $125 to win $100) / Cowboys +105 (bet $100 to win $105) | Bet now
  • Against the spread: 49ers -1.5, -110 (bet $110 to win $100) / Cowboys +1.5, -110 (bet $110 to win $100) | Bet now
  • Total: 44.5, Over -115 (bet $115 to win $100) / Under -105 (bet $105 to win $100) | Bet now

New to NFL betting?

The 49ers, at -125 odds, have an implied 55.56% chance of winning, or 4/5 fractional odds. If San Francisco wins by more than 1 point, a 49ers -1.5 (-110) bet wins.

Place your legal, online NFL bets in CO, IN, NJ, TN and WV at BetMGM. Risk-free first bet! Terms and conditions apply. Bet now!

At +105 odds, the Cowboys have an implied 48.78% chance of beating the 49ers or 21/20 fractional odds. Dallas must win outright, tie or lose by only one point for a Cowboys +1.5 (-110) ATS ticket to cash.

Also see:

Get some action on this NFL game or others by signing up and betting at BetMGM. If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com. Please gamble responsibly.

Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from audience referrals to betting services.  Newsrooms are independent of this relationship and there is no influence on news coverage.

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