Arizona Cardinals home favorites over San Francisco 49ers in Week 16

The San Francisco 49ers are underdogs in their Week 16 home matchup with the rival Arizona Cardinals.

The Arizona Cardinals (8-6) play their home finale in Week 16 against the San Francisco 49ers (5-9). The two teams will play in one of three Saturday games, kicking off at 4:30 p.m. at State Farm Stadium in Glendale, AZ. Below, we take a look at the early betting odds and lines at BetMGM Sportsbook.

The Cardinals are coming off their second straight win. QB Kyler Murray passed for a career-high 406 yards and had three touchdown passes and a rushing touchdown in a 33-26 victory over the Philadelphia Eagles.

The 49ers lost their third straight game on Sunday, and sixth in their last seven games, falling 41-33 to the Dallas Cowboys. 49ers QB Nick Mullens had two interceptions and lost a fumble, and the team turned the ball over four times in the loss.

49ers at Cardinals betting odds, spread and line

Odds via BetMGM; last updated Monday at 7:55 p.m. ET. 

  • Money line: 49ers +160 (bet $100 to win $160) / Cardinals -190 (bet $190 to win $100) | Bet now
  • Against the spread: 49ers +4, -110 (bet $110 to win $100) / Cardinals -4, -110 (bet $110 to win $100) | Bet now
  • Total: 48.5, Over -110 (bet $110 to win $100) / Under -110 (bet $110 to win $100) | Bet now

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The 49ers, at +160 odds, have an implied 38.46% chance of winning, or 8/5 fractional odds. If San Francisco wins outright or loses by fewer than 4 points, a 49ers +4 (-110) bet wins.

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At -190 odds, the Cardinals have an implied 65.52% chance of beating the 49ers or 10/19 fractional odds. Arizona must win by 5 or more points for a Cardinals -4 (-110) ATS ticket to cash. A 4-point Arizona win would result in a push.

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