San Francisco 49ers at Miami Dolphins odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Miami Dolphins odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (6-8) and Miami Dolphins (6-8) meet Sunday. Kickoff from Hard Rock Stadium is set for 4:25 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Dolphins odds, and make our expert NFL picks and predictions.

The 49ers have lost 4 of their last 5 games and are coming off a 12-6 home loss to the LA Rams Dec. 12 as 2.5-point favorites.

The Dolphins are coming off a 20-12 loss at the Houston Texans Dec. 15, failing to cover the spread as 2.5-point underdogs. It was their second loss in the last 3 games after winning 3 in a row Nov. 11-24.

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49ers at Dolphins odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 4:27 p.m. ET.

  • Moneyline (ML): 49ers -115 (bet $115 to win $100) | Dolphins -105 (bet $105 to win $100)
  • Against the spread (ATS): 49ers -1 (-110) | Dolphins +1 (-110)
  • Over/Under (O/U): 44.5 (O: -110 | U: -110)

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49ers at Dolphins key injuries

49ers

  • DE Robert Beal Jr. (ankle) questionable
  • DE Nick Bosa (hip, oblique) questionable
  • LB Dre Greenlaw (Achilles, knee) questionable
  • RB Isaac Guerendo (hamstring) out
  • LT Trent Williams (ankle) out

Dolphins

  • OT Terron Armstead (knee) questionable
  • LB Bradley Chubb (knee) questionable
  • WR Dee Eskridge (knee) doubtful
  • LS Blake Ferguson (non-football illness) out
  • LB Cameron Goode (knee) questionable
  • WR Tyreek Hill (wrist/personal) questionable
  • OT Kendall Lamm (back) questionable
  • WR Jaylen Waddle (knee) doubtful

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49ers at Dolphins picks and predictions

Prediction

Dolphins 24, 49ers 17

Moneyline

The Niners are down to their fourth-string RB in Patrick Taylor Jr., as Guerendo is out and Christian McCaffrey and Jordan Mason are on injured reserve. They also are without their starting left tackle.

They have scored 10 or fewer points in 3 of their last 4 games.

The Dolphins have averaged 25.8 points in their last 8 games since QB Tua Tagovailoa returned from injured reserve.

BET DOLPHINS (-105).

Against the spread

Taking the point and having to pay an extra 5 cents on the dollar isn’t worth the safety net of pushing on a 1-point straight-up loss.

PASS.

Over/Under

The Niners have allowed a combined 25 points in their last 2 games despite giving up 24 or more in 6 of the previous 8.

The Dolphins have held opponents to 20 or fewer points in 4 of their last 6 games.

BET UNDER 44.5 (-110).

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