San Francisco Giants at Chicago Cubs odds, picks and predictions

Analyzing Monday’s San Francisco Giants at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago Cubs (34-38) welcome the San Francisco Giants (35-37) to Wrigley Field Monday. First pitch to kick off the 3-game series is set for 8:05 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Cubs won 5-1 last season

The Cubs, who are 19-15 at home this season, lost 2-1 to the St. Louis Cardinals at Wrigley Sunday. They dropped 2 of 3 in the series. Chicago has lost 3 straight series and is 3-7 straight up over its last 10 games. The Cubs have been a bit better against the spread (ATS) recently, having gone 4-3 ATS over their last 7.

The Giants lost 2 of 3 to the Los Angeles Angels in their last series, winning the final game 13-6 Sunday. San Francisco is 6-4 straight up over its last 10 and 6-4 ATS in those games. It is 34-38 ATS on the season and 15-20 in road games.

Giants at Cubs projected starters

RHP Jordan Hicks vs. RHP Javier Assad

Hicks (4-3, 3.01 ERA) makes his 15th start. He has a 1.20 WHIP, 3.0 BB/9 and 8.0 K/9 in 71 2/3 innings.

  • Last start: Loss, 4 2/3 IP, 3 ER, 5 H, 1 BB, 5 K in 3-1 home loss to Houston Astros Tuesday
  • 2024 road splits: 2-1, 3.25 ERA (27 2/3 IP, 10 ER), 1.48 WHIP, 1 HR, 11.1 K/9 in 6 starts
  • Career vs. Cubs: 2-1, 3.60 ERA (20 IP, 8 ER), 1.00 WHIP, 8.6 K/9 in 18 relief appearances

Assad (4-2, 2.81 ERA) makes his 15th start. He has a 1.24 WHIP, 3.7 BB/9 and 8.8 K/9 in 72 2/3 innings.

  • Last start: No-decision, 4 2/3 IP, 2 ER, 5 H, 2 BB, 4 K in 4-3 road win over Tampa Bay Rays Wednesday
  • 2024 home splits: 2-0, 1.67 ERA (32 1/3 IP, 6 ER), 1.24 WHIP, 2 HR, 7.8 K/9 in 6 starts
  • Career vs. Giants: 0-0, 13.50 ERA (2 IP, 3 ER), 5 H, 1 BB, 1 K in 1 relief appearance of 13-3 road loss June 11, 2023

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Giants at Cubs odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:53 a.m. ET.

  • Moneyline (ML): Giants +102 (bet $100 to win $102) | Cubs -120 (bet $120 to win $100)
  • Run line (RL)/Against the spread: Giants -1.5 (+158) | Cubs +1.5 (-192)
  • Over/Under (O/U): 10 (O: -120 | U: -102)

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Giants at Cubs picks and predictions

Prediction

Cubs 5, Giants 3

Moneyline

BET CUBS (-120).

The Cubs are 5-3 in Assad’s last 8 starts, while the Giants have lost 2 of Hicks’ last 3. San Francisco has struggled as of late, dropping 3 of its last 5. It is 3-4 straight up in its last 7 on the road as well. Chicago is one of the best teams in MLB after a loss, posting a 22-15 record.

Meanwhile, San Francisco is coming off a win and is just 14-20 in games following. Couple those trends, along with the Cubs being better at home and the Giants worse on the road, and back CUBS (-120).

Run line/Against the spread

PASS.

There’s just no great value here. The Giants are too risky as run-line favorites, while the Cubs are far too expensive as run-line underdogs. Avoid this play.

Over/Under

BET UNDER 10 (-102).

Both teams have strong pitchers taking the mound to start the game. The Cubs have gone Under in 9 straight games and are 30-39-3 O/U on the season.

They have scored 2 or fewer in 3 of their last 4 and have allowed 3 or fewer in 5 straight. The Giants are 4-5 O/U in their last 9 and have allowed 3 or fewer in 4 of their last 6. Take UNDER 10 (-102).

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